Histopathological changes in the gastrointestinal tract due to drugs: An update for the surgical pathologist (part I of II)

Giovanni De Petris, Sonia Gatius Caldero, Longwen Chen, Shu Yuan Xiao, Bal M. Dhungel, Amy J. Wendel Spizcka, Dora Lam-Himlin

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Abnormalities of the gastrointestinal (GI) tract due to drugs (AGIDs) are numerous and have significant impact. The aim of this narrative review is to help the practicing surgical pathologist recognize selected AGIDs. The adverse drug effects presented were chosen with an emphasis on recent and significant pathological and clinical contributions. The selection was based on a thorough review of the PUBMED-based literature and on the authors' opinions and experience. In the first part of the review, diagnostic abnormalities due to crystals (eg, iron, biphosphonates, nonsystemic drugs), mitosis arresting drugs (colchicine, taxanes), and biological agents, especially ipilimumab, are discussed. Some AGIDs' histopathologic features can be easily recognized. It is however the clinical correlation that in many cases of AGIDs will provide the necessary support for a drug effect diagnosis. The identification of AGIDs requires heightened awareness of the medical team in which close collaboration of pathologists and clinicians cannot be overemphasized.

Original languageEnglish (US)
Pages (from-to)120-128
Number of pages9
JournalInternational Journal of Surgical Pathology
Volume22
Issue number2
DOIs
StatePublished - Apr 2014

    Fingerprint

Keywords

  • adverse gastrointestinal tract drug effect
  • crystals in the gastrointestinal tract
  • ipilimumab
  • nonsteroidal anti-inflammatory drugs
  • olmesartan

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

De Petris, G., Gatius Caldero, S., Chen, L., Xiao, S. Y., Dhungel, B. M., Wendel Spizcka, A. J., & Lam-Himlin, D. (2014). Histopathological changes in the gastrointestinal tract due to drugs: An update for the surgical pathologist (part I of II). International Journal of Surgical Pathology, 22(2), 120-128. https://doi.org/10.1177/1066896913502229