TY - JOUR
T1 - Histopathologic assessment of suspected idiopathic pulmonary fibrosis
T2 - Where we are and where we need to go
AU - Smith, Maxwell L.
AU - Hariri, Lida P.
AU - Mino-Kenudson, Mari
AU - Dacic, Sanja
AU - Attanoos, Richard
AU - Borczuk, Alain
AU - Colby, Thomas V.
AU - Cooper, Wendy
AU - Jones, Kirk D.
AU - Leslie, Kevin O.
AU - Mahar, Annabelle
AU - Larsen, Brandon T.
AU - Cavazza, Alberto
AU - Fukuoka, Jun
AU - Roden, Anja C.
AU - Sholl, Lynette M.
AU - Tazelaar, Henry D.
AU - Churg, Andrew
AU - Beasley, Mary Beth
N1 - Publisher Copyright:
© 2020 College of American Pathologists. All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Context. - Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) requires multidisciplinary diagnosis that includes clinical, radiologic, and often pathologic assessment. In 2018, the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and the Latin American Thoracic Society (ATS/ERS/JRS/ALAT) and the Fleischner Society each published guidelines for the diagnosis of IPF, which include criteria for 4 categories of confidence of a histologic usual interstitial pneumonia (UIP) pattern. Objective. - To (1) identify the role of the guidelines in pathologic assessment of UIP; (2) analyze the 4 guideline categories, including potential areas of difficulty; and (3) determine steps the Pulmonary Pathology Society and the greater pulmonary pathology community can take to improve current guideline criteria and histopathologic diagnosis of interstitial lung disease. Data Sources. - Data were derived from the guidelines, published literature, and clinical experience. Conclusions. - Both guidelines provide pathologists with a tool to relay to the clinician the likelihood that a biopsy represents UIP, and serve as an adjunct, not a replacement, for traditional histologic diagnosis. There are multiple challenges with implementing the guidelines, including (1) lack of clarity on the quantity and quality of histologic findings required, (2) lack of recognition that histologic features cannot be assessed independently, and (3) lack of guidance on how pathologists should incorporate clinical and radiographic information. Current criteria for ''probable UIP'' and ''indeterminate for UIP'' hinder accurate reflection of the likelihood of IPF. These challenges highlight the need for further morphologic-based investigations in the field of pulmonary pathology.
AB - Context. - Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) requires multidisciplinary diagnosis that includes clinical, radiologic, and often pathologic assessment. In 2018, the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and the Latin American Thoracic Society (ATS/ERS/JRS/ALAT) and the Fleischner Society each published guidelines for the diagnosis of IPF, which include criteria for 4 categories of confidence of a histologic usual interstitial pneumonia (UIP) pattern. Objective. - To (1) identify the role of the guidelines in pathologic assessment of UIP; (2) analyze the 4 guideline categories, including potential areas of difficulty; and (3) determine steps the Pulmonary Pathology Society and the greater pulmonary pathology community can take to improve current guideline criteria and histopathologic diagnosis of interstitial lung disease. Data Sources. - Data were derived from the guidelines, published literature, and clinical experience. Conclusions. - Both guidelines provide pathologists with a tool to relay to the clinician the likelihood that a biopsy represents UIP, and serve as an adjunct, not a replacement, for traditional histologic diagnosis. There are multiple challenges with implementing the guidelines, including (1) lack of clarity on the quantity and quality of histologic findings required, (2) lack of recognition that histologic features cannot be assessed independently, and (3) lack of guidance on how pathologists should incorporate clinical and radiographic information. Current criteria for ''probable UIP'' and ''indeterminate for UIP'' hinder accurate reflection of the likelihood of IPF. These challenges highlight the need for further morphologic-based investigations in the field of pulmonary pathology.
UR - http://www.scopus.com/inward/record.url?scp=85096886189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096886189&partnerID=8YFLogxK
U2 - 10.5858/arpa.2020-0052-RA
DO - 10.5858/arpa.2020-0052-RA
M3 - Article
C2 - 32614648
AN - SCOPUS:85096886189
SN - 0003-9985
VL - 144
SP - 1477
EP - 1489
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 12
ER -