Histone modifications and chromatin organization in prostate cancer

Zhong Chen, Liguo Wang, Qianben Wang, Wei Li

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

Epigenetic mechanisms, including histone modifications, nucleosomal remodeling and chromosomal looping, contribute to the onset and progression of prostate cancer. Recent technical advances significantly increase our understanding of the genome-wide epigenetic regulation of gene expression in prostate cancer. Aberrant genomic distribution and global level of histone modifications, nucleosome repositioning at the gene promoter and enhancer regions, as well as androgen receptor-mediated chromosomal looping may lead to the silencing of tumor suppressor genes and the activation of proto-oncogenes. In addition, androgen receptor-induced chromosomal looping facilitates recurrent gene fusion in prostate cancer. Studies in epigenetic regulation have translational implications in the identification of new biomarkers and the development of new therapies in prostate cancer.

Original languageEnglish (US)
Pages (from-to)551-560
Number of pages10
JournalEpigenomics
Volume2
Issue number4
DOIs
StatePublished - Aug 1 2010

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Keywords

  • CHIA-PET
  • ChIP-seq
  • Hi-C
  • bioinformatics
  • chromatin organization
  • epigenome
  • histone modification
  • next-generation sequencing
  • prostate cancer

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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