Histone gene transcription: A model for responsiveness to an integrated series of regulatory signals mediating cell cycle control and proliferation/differentiation interrelationships

Gary S. Stein, Janet L. Stein, André J. van Wijnen, Jane B. Lian

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Histone gene expression is restricted to the S‐phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell cycle progression and the onset of differentiation. The H4 gene promoter is organized into a series of independent and overlapping regulatory elements which exhibit selective, phosphorylation‐dependent interactions with multiple transactivation factors. The three‐dimensional organization of the promoter and, in particular, its chromatin structure, nucleosome organization, and interactions with the nuclear matrix may contribute to interrelationships of activities at multiple promoter elements. Molecular mechanisms are discussed that may participate in the coordinate expression of S‐phase‐specific core and H1 histone genes, together with other genes functionally coupled with DNA replication.

Original languageEnglish (US)
Pages (from-to)393-404
Number of pages12
JournalJournal of cellular biochemistry
Volume54
Issue number4
DOIs
StatePublished - Apr 1994

Keywords

  • S‐phase
  • cell cycle control
  • differentiation
  • histone gene expression
  • regulatory signals

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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