TY - JOUR
T1 - Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces akt phosphorylation
AU - Dudakovic, Amel
AU - Evans, Jared M.
AU - Li, Ying
AU - Middha, Sumit
AU - McGee-Lawrence, Meghan E.
AU - Van Wijnen, Andre J.
AU - Westendorf, Jennifer J.
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:Histone deacetylase (HDAC) inhibition promotes bone formationin vitrovia undefined epigenetic events. Results:Microarray and ChIP-Seq analyses revealed genomic areas where H4 acetylation is altered by HDAC inhibitors and identified differentially regulated genes. Conclusion:Suberoylanilide hydroxamic acid increases H4 acetylation and suppresses phosphorylation of insulin/Akt signaling mediators in osteoblasts. Significance:Epigenetic profiling is a powerful means to gain mechanistic insights into bone anabolic processes.
AB - Background:Histone deacetylase (HDAC) inhibition promotes bone formationin vitrovia undefined epigenetic events. Results:Microarray and ChIP-Seq analyses revealed genomic areas where H4 acetylation is altered by HDAC inhibitors and identified differentially regulated genes. Conclusion:Suberoylanilide hydroxamic acid increases H4 acetylation and suppresses phosphorylation of insulin/Akt signaling mediators in osteoblasts. Significance:Epigenetic profiling is a powerful means to gain mechanistic insights into bone anabolic processes.
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U2 - 10.1074/jbc.M113.489732
DO - 10.1074/jbc.M113.489732
M3 - Article
C2 - 23940046
AN - SCOPUS:84885164156
VL - 288
SP - 28783
EP - 28791
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 40
ER -