Abstract
Background:Histone deacetylase (HDAC) inhibition promotes bone formationin vitrovia undefined epigenetic events. Results:Microarray and ChIP-Seq analyses revealed genomic areas where H4 acetylation is altered by HDAC inhibitors and identified differentially regulated genes. Conclusion:Suberoylanilide hydroxamic acid increases H4 acetylation and suppresses phosphorylation of insulin/Akt signaling mediators in osteoblasts. Significance:Epigenetic profiling is a powerful means to gain mechanistic insights into bone anabolic processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28783-28791 |
| Number of pages | 9 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 40 |
| DOIs | |
| State | Published - Oct 4 2013 |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces akt phosphorylation. / Dudakovic, Amel; Evans, Jared M.; Li, Ying; Middha, Sumit; McGee-Lawrence, Meghan E.; van Wijnen, Andre J; Westendorf, Jennifer J.
In: Journal of Biological Chemistry, Vol. 288, No. 40, 04.10.2013, p. 28783-28791.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces akt phosphorylation
AU - Dudakovic, Amel
AU - Evans, Jared M.
AU - Li, Ying
AU - Middha, Sumit
AU - McGee-Lawrence, Meghan E.
AU - van Wijnen, Andre J
AU - Westendorf, Jennifer J
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:Histone deacetylase (HDAC) inhibition promotes bone formationin vitrovia undefined epigenetic events. Results:Microarray and ChIP-Seq analyses revealed genomic areas where H4 acetylation is altered by HDAC inhibitors and identified differentially regulated genes. Conclusion:Suberoylanilide hydroxamic acid increases H4 acetylation and suppresses phosphorylation of insulin/Akt signaling mediators in osteoblasts. Significance:Epigenetic profiling is a powerful means to gain mechanistic insights into bone anabolic processes.
AB - Background:Histone deacetylase (HDAC) inhibition promotes bone formationin vitrovia undefined epigenetic events. Results:Microarray and ChIP-Seq analyses revealed genomic areas where H4 acetylation is altered by HDAC inhibitors and identified differentially regulated genes. Conclusion:Suberoylanilide hydroxamic acid increases H4 acetylation and suppresses phosphorylation of insulin/Akt signaling mediators in osteoblasts. Significance:Epigenetic profiling is a powerful means to gain mechanistic insights into bone anabolic processes.
UR - http://www.scopus.com/inward/record.url?scp=84885164156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885164156&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.489732
DO - 10.1074/jbc.M113.489732
M3 - Article
VL - 288
SP - 28783
EP - 28791
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 40
ER -