Abstract
Background:Histone deacetylase (HDAC) inhibition promotes bone formationin vitrovia undefined epigenetic events. Results:Microarray and ChIP-Seq analyses revealed genomic areas where H4 acetylation is altered by HDAC inhibitors and identified differentially regulated genes. Conclusion:Suberoylanilide hydroxamic acid increases H4 acetylation and suppresses phosphorylation of insulin/Akt signaling mediators in osteoblasts. Significance:Epigenetic profiling is a powerful means to gain mechanistic insights into bone anabolic processes.
Original language | English (US) |
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Pages (from-to) | 28783-28791 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 40 |
DOIs | |
State | Published - Oct 4 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology