TY - JOUR
T1 - Histological grades and prognostic markers of well-differentiated pancreatic neuroendocrine tumor (WDPNET)
AU - Li, Yongchao
AU - Rowan, Daniel
AU - Williamson, Claire P.
AU - Fan, Meiyun
AU - Saad, Ali G.
AU - Zhang, Lizhi
N1 - Publisher Copyright:
© 2020 LWW. All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - AbstractPancreatic neuroendocrine tumors (PNETs) are the second most common neoplasm of the pancreas after ductal adenocarcinoma. The clinical behavior of PNETs is very difficult to predict, especially for well-differentiated PNETs. Several classification systems have been developed to differentiate benign from malignant PNETs. The current 5th edition WHO (2019) updated the grading system of PNETs which is now entirely based on proliferative rate (either mitotic count or Ki-67 index). In this article, we systemically reviewed the evolution of the histologic classification and grading systems for well-differentiated PNETs. Meanwhile, we also report a comprehensive summary of immunohistochemical and molecular prognostic factors for PNETs patients, including CK19, KIT, PD-L1/PD-L1, UCH-L1 and CNPY2. We believe that more reliable grading systems and prognostic markers are emerging and will change the landscape of treatment for well-differentiated PNETs.
AB - AbstractPancreatic neuroendocrine tumors (PNETs) are the second most common neoplasm of the pancreas after ductal adenocarcinoma. The clinical behavior of PNETs is very difficult to predict, especially for well-differentiated PNETs. Several classification systems have been developed to differentiate benign from malignant PNETs. The current 5th edition WHO (2019) updated the grading system of PNETs which is now entirely based on proliferative rate (either mitotic count or Ki-67 index). In this article, we systemically reviewed the evolution of the histologic classification and grading systems for well-differentiated PNETs. Meanwhile, we also report a comprehensive summary of immunohistochemical and molecular prognostic factors for PNETs patients, including CK19, KIT, PD-L1/PD-L1, UCH-L1 and CNPY2. We believe that more reliable grading systems and prognostic markers are emerging and will change the landscape of treatment for well-differentiated PNETs.
KW - Grading, Ki-67, PNETs, Prognosis
UR - http://www.scopus.com/inward/record.url?scp=85104413504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85104413504&partnerID=8YFLogxK
U2 - 10.1097/JP9.0000000000000061
DO - 10.1097/JP9.0000000000000061
M3 - Review article
AN - SCOPUS:85104413504
SN - 2096-5664
VL - 3
SP - 188
EP - 194
JO - Journal of Pancreatology
JF - Journal of Pancreatology
IS - 4
ER -