Histological findings of birdshot chorioretinopathy in an eye with ciliochoroidal melanoma

J. S. Pulido, I. Canal, D. Salomão, D. Kravitz, E. Bradley, R. Vile

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Purpose: To describe the histological findings of birdshot chorioretinopathy. Design/participant: This is a case study of a single patient who has both birdshot chorioretinopathy and ciliochoroidal melanoma. Methods: A 55-year-old woman who was HLA-A29 positive and had birdshot chorioretinopathy had a large ciliochoroidal melanoma (T4b N0 M0) and underwent enucleation. Outcome measures: Using histopathology, we hope to further define the pathological findings in an eye with both birdshot chorioretinopathy and coexistant ciliochoroidal melanomas. Results: The eye showed a ciliochoroidal melanoma. In addition, elsewhere, there were multiple choroidal nodules of lymphocytes that showed the presence of CD3-positive cells, which also stained for CD4 or CD8. There were only a few CD20-positive B cells and rare CD68-positive histiocytes. No granulomas were present. Discussion: To our knowledge, there are only two previous reports describing the histological findings in birdshot chorioretinopathy: one that was HLA-A29 negative showing choroidal granulomas and another that was HLA-A29 positive exhibiting histological findings similar to our case. Incidentally, the latter case had a history of cutaneous melanoma. Conclusion: Birdshot chorioretinopathy is a nongranulomatous nodular infiltration of the choroid.

Original languageEnglish (US)
Pages (from-to)862-865
Number of pages4
JournalEye (Basingstoke)
Volume26
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • HLA-A29
  • birdshot chorioretinopathy
  • melanoma
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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