Histological findings of birdshot chorioretinopathy in an eye with ciliochoroidal melanoma

Jose S Pulido, I. Canal, D. Salomão, D. Kravitz, E. Bradley, Richard Geoffrey Vile

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose: To describe the histological findings of birdshot chorioretinopathy. Design/participant: This is a case study of a single patient who has both birdshot chorioretinopathy and ciliochoroidal melanoma. Methods: A 55-year-old woman who was HLA-A29 positive and had birdshot chorioretinopathy had a large ciliochoroidal melanoma (T4b N0 M0) and underwent enucleation. Outcome measures: Using histopathology, we hope to further define the pathological findings in an eye with both birdshot chorioretinopathy and coexistant ciliochoroidal melanomas. Results: The eye showed a ciliochoroidal melanoma. In addition, elsewhere, there were multiple choroidal nodules of lymphocytes that showed the presence of CD3-positive cells, which also stained for CD4 or CD8. There were only a few CD20-positive B cells and rare CD68-positive histiocytes. No granulomas were present. Discussion: To our knowledge, there are only two previous reports describing the histological findings in birdshot chorioretinopathy: one that was HLA-A29 negative showing choroidal granulomas and another that was HLA-A29 positive exhibiting histological findings similar to our case. Incidentally, the latter case had a history of cutaneous melanoma. Conclusion: Birdshot chorioretinopathy is a nongranulomatous nodular infiltration of the choroid.

Original languageEnglish (US)
Pages (from-to)862-865
Number of pages4
JournalEye (Basingstoke)
Volume26
Issue number6
DOIs
StatePublished - Jun 2012

Fingerprint

Melanoma
Granuloma
Histiocytes
Choroid
Birdshot chorioretinopathy
B-Lymphocytes
Outcome Assessment (Health Care)
Lymphocytes
Skin
HLA-A29 antigen

Keywords

  • birdshot chorioretinopathy
  • HLA-A29
  • melanoma
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Histological findings of birdshot chorioretinopathy in an eye with ciliochoroidal melanoma. / Pulido, Jose S; Canal, I.; Salomão, D.; Kravitz, D.; Bradley, E.; Vile, Richard Geoffrey.

In: Eye (Basingstoke), Vol. 26, No. 6, 06.2012, p. 862-865.

Research output: Contribution to journalArticle

Pulido, Jose S ; Canal, I. ; Salomão, D. ; Kravitz, D. ; Bradley, E. ; Vile, Richard Geoffrey. / Histological findings of birdshot chorioretinopathy in an eye with ciliochoroidal melanoma. In: Eye (Basingstoke). 2012 ; Vol. 26, No. 6. pp. 862-865.
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