Histologic remission of cardiac amyloidosis: A case report

Matthew R. Nelson, Louis A. Lanza, Craig B. Reeder, Robert L. Scott, Ann E. McCullough, Krishnaswamy Chandrasekaran, Roger L. Click

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The main determinant of survival in amyloid light chain amyloidosis is cardiac involvement. The rate of change in wall thickness may be a strong predictor of survival. After treatment, some hematologic responders have had documented regression of wall thickness by echocardiography with resolution of heart failure symptoms. Herein, we demonstrate a case of treated immunoglobulin light chain cardiac amyloidosis with echocardiographic wall thinning and cardiac biopsies demonstrating complete histologic remission. This observation suggests a mechanism of treatment response and that with appropriately timed treatment, cardiac deposition of amyloid fibrils can be completely reversed.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalAmyloid
Volume19
Issue number2
DOIs
StatePublished - Jun 1 2012

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Keywords

  • Biopsy
  • Cardiac amyloid
  • Echocardiography
  • Histologic regression

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Nelson, M. R., Lanza, L. A., Reeder, C. B., Scott, R. L., McCullough, A. E., Chandrasekaran, K., & Click, R. L. (2012). Histologic remission of cardiac amyloidosis: A case report. Amyloid, 19(2), 106-109. https://doi.org/10.3109/13506129.2012.660892