Histologic findings after surgical excision of optic nerve head drusen

Rashmi Kapur, Jose S Pulido, Jerrold L. Abraham, Mithlesh Sharma, Bruce Buerk, Deepak P. Edward

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

PURPOSE: To report the histopathologic findings of a case of bilateral massive optic nerve head (ONH) drusen. METHODS: A 59-year-old man presented with bilateral massive ONH drusen and secondary compromise of the retinal vasculature leading to vision of counting fingers at 1 ft in the left eye and 20/30 in the right eye. The inferior one half of the left ONH druse was excised resulting in no light perception vision postoperatively. RESULTS: Energy-dispersive spectroscopy suggested the composition of the ONH druse to be calcium phosphate (Ca3[PO4]2), which has implications on pathogenesis of neuronal cell death in ONH drusen. Scanning electron microscopy demonstrated embedded metal particles, likely to be remnants of the instruments used. CONCLUSION: Massive ONH drusen are actually one large druse that has multiple excrescences on its surface giving it the variegated appearance. Although surgical excision of ONH drusen may be technically possible, consideration should be given to improvements in instrumentation and patient selection criteria.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalRetina
Volume28
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Optic Disk Drusen
Optic Disk
Patient Selection
Electron Scanning Microscopy
Fingers
Spectrum Analysis
Cell Death
Metals
Light

Keywords

  • Disk drusen
  • Optic nerve head drusen
  • Vitrectomy

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Kapur, R., Pulido, J. S., Abraham, J. L., Sharma, M., Buerk, B., & Edward, D. P. (2008). Histologic findings after surgical excision of optic nerve head drusen. Retina, 28(1), 143-146. https://doi.org/10.1097/IAE.0b013e31815e98d8

Histologic findings after surgical excision of optic nerve head drusen. / Kapur, Rashmi; Pulido, Jose S; Abraham, Jerrold L.; Sharma, Mithlesh; Buerk, Bruce; Edward, Deepak P.

In: Retina, Vol. 28, No. 1, 01.2008, p. 143-146.

Research output: Contribution to journalArticle

Kapur, R, Pulido, JS, Abraham, JL, Sharma, M, Buerk, B & Edward, DP 2008, 'Histologic findings after surgical excision of optic nerve head drusen', Retina, vol. 28, no. 1, pp. 143-146. https://doi.org/10.1097/IAE.0b013e31815e98d8
Kapur, Rashmi ; Pulido, Jose S ; Abraham, Jerrold L. ; Sharma, Mithlesh ; Buerk, Bruce ; Edward, Deepak P. / Histologic findings after surgical excision of optic nerve head drusen. In: Retina. 2008 ; Vol. 28, No. 1. pp. 143-146.
@article{0375b5c8c14c469abe52015f501dfd2b,
title = "Histologic findings after surgical excision of optic nerve head drusen",
abstract = "PURPOSE: To report the histopathologic findings of a case of bilateral massive optic nerve head (ONH) drusen. METHODS: A 59-year-old man presented with bilateral massive ONH drusen and secondary compromise of the retinal vasculature leading to vision of counting fingers at 1 ft in the left eye and 20/30 in the right eye. The inferior one half of the left ONH druse was excised resulting in no light perception vision postoperatively. RESULTS: Energy-dispersive spectroscopy suggested the composition of the ONH druse to be calcium phosphate (Ca3[PO4]2), which has implications on pathogenesis of neuronal cell death in ONH drusen. Scanning electron microscopy demonstrated embedded metal particles, likely to be remnants of the instruments used. CONCLUSION: Massive ONH drusen are actually one large druse that has multiple excrescences on its surface giving it the variegated appearance. Although surgical excision of ONH drusen may be technically possible, consideration should be given to improvements in instrumentation and patient selection criteria.",
keywords = "Disk drusen, Optic nerve head drusen, Vitrectomy",
author = "Rashmi Kapur and Pulido, {Jose S} and Abraham, {Jerrold L.} and Mithlesh Sharma and Bruce Buerk and Edward, {Deepak P.}",
year = "2008",
month = "1",
doi = "10.1097/IAE.0b013e31815e98d8",
language = "English (US)",
volume = "28",
pages = "143--146",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Histologic findings after surgical excision of optic nerve head drusen

AU - Kapur, Rashmi

AU - Pulido, Jose S

AU - Abraham, Jerrold L.

AU - Sharma, Mithlesh

AU - Buerk, Bruce

AU - Edward, Deepak P.

PY - 2008/1

Y1 - 2008/1

N2 - PURPOSE: To report the histopathologic findings of a case of bilateral massive optic nerve head (ONH) drusen. METHODS: A 59-year-old man presented with bilateral massive ONH drusen and secondary compromise of the retinal vasculature leading to vision of counting fingers at 1 ft in the left eye and 20/30 in the right eye. The inferior one half of the left ONH druse was excised resulting in no light perception vision postoperatively. RESULTS: Energy-dispersive spectroscopy suggested the composition of the ONH druse to be calcium phosphate (Ca3[PO4]2), which has implications on pathogenesis of neuronal cell death in ONH drusen. Scanning electron microscopy demonstrated embedded metal particles, likely to be remnants of the instruments used. CONCLUSION: Massive ONH drusen are actually one large druse that has multiple excrescences on its surface giving it the variegated appearance. Although surgical excision of ONH drusen may be technically possible, consideration should be given to improvements in instrumentation and patient selection criteria.

AB - PURPOSE: To report the histopathologic findings of a case of bilateral massive optic nerve head (ONH) drusen. METHODS: A 59-year-old man presented with bilateral massive ONH drusen and secondary compromise of the retinal vasculature leading to vision of counting fingers at 1 ft in the left eye and 20/30 in the right eye. The inferior one half of the left ONH druse was excised resulting in no light perception vision postoperatively. RESULTS: Energy-dispersive spectroscopy suggested the composition of the ONH druse to be calcium phosphate (Ca3[PO4]2), which has implications on pathogenesis of neuronal cell death in ONH drusen. Scanning electron microscopy demonstrated embedded metal particles, likely to be remnants of the instruments used. CONCLUSION: Massive ONH drusen are actually one large druse that has multiple excrescences on its surface giving it the variegated appearance. Although surgical excision of ONH drusen may be technically possible, consideration should be given to improvements in instrumentation and patient selection criteria.

KW - Disk drusen

KW - Optic nerve head drusen

KW - Vitrectomy

UR - http://www.scopus.com/inward/record.url?scp=38049110193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049110193&partnerID=8YFLogxK

U2 - 10.1097/IAE.0b013e31815e98d8

DO - 10.1097/IAE.0b013e31815e98d8

M3 - Article

C2 - 18185151

AN - SCOPUS:38049110193

VL - 28

SP - 143

EP - 146

JO - Retina

JF - Retina

SN - 0275-004X

IS - 1

ER -