Histologic evaluation in the diagnosis and management of celiac disease: practical challenges, current best practice recommendations and beyond

Zongming Eric Chen, Hee Eun Lee, Tsung Teh Wu

Research output: Contribution to journalReview articlepeer-review

Abstract

Celiac disease (CD) is an immunoallergic enteropathy affecting genetically susceptible individuals upon dietary exposure to gluten. In current clinical practice, the diagnosis of CD is based on a combination of clinical, serologic, and histologic factors with the possible exception of pediatric patients. Histopathologic evaluation of small intestinal tissue plays a critical role in the disease diagnosis and management, despite many practical challenges. Recently published best practice guidelines help to standardize biopsy sample procurement, tissue preparation, histology interpretation, and reporting, to optimize patient care. In addition, an increasing demand for monitoring the disease course, particularly demonstrating the efficacy of dietary and nondietary interventions for disease management, calls for the use of quantitative histology. With the advent of a gradual transition toward digital pathology in routine diagnostic practice, quantitative histopathologic evaluation in CD shows a promising future.

Original languageEnglish (US)
JournalHuman Pathology
DOIs
StateAccepted/In press - 2022

Keywords

  • Celiac disease
  • Collagenous sprue
  • Q-MARSH
  • Refractory celiac disease
  • Ultrashort celiac disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint

Dive into the research topics of 'Histologic evaluation in the diagnosis and management of celiac disease: practical challenges, current best practice recommendations and beyond'. Together they form a unique fingerprint.

Cite this