Histologic changes in diabetic gastroparesis

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

The cellular abnormalities that lead to diabetic gastroparesis are increasingly being understood. Several key cell types are affected by diabetes, leading to gastroparesis. These changes include abnormalities in the extrinsic innervation to the stomach, loss of key neurotransmitters at the level of the enteric nervous system, smooth muscle abnormalities, loss of interstitial cells of Cajal, and changes in the macrophage population resident in the muscle wall. This article reviews the current understanding with a focus on data from human studies when available.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalGastroenterology Clinics of North America
Volume44
Issue number1
DOIs
StatePublished - Mar 1 2015

Keywords

  • Enteric nerves
  • Gastric emptying
  • Interstitial cells of cajal
  • Macrophages
  • Smooth muscle
  • Vagus

ASJC Scopus subject areas

  • Gastroenterology

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