Histologic analysis of a human trigeminal nerve after failed stereotactic radiosurgery: case report

Andrew B. Foy, Joseph E Parisi, Bruce E. Pollock

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Stereotactic radiosurgery is an accepted surgery to treat patients with medically intractable trigeminal neuralgia. However, little is known about the mechanism of pain relief after trigeminal neuralgia radiosurgery. We report the histologic findings of a human trigeminal nerve after failed radiosurgery for trigeminal neuralgia. Case Description: A 74-year-old patient presented with a 10-year history of refractory trigeminal neuralgia. Prior surgeries included an MVD and PRGR. Gamma knife radiosurgery was performed targeting the proximal trigeminal nerve using one 4-mm isocenter (maximum dose, 85 Gy). She experienced good pain relief (no pain, reduced medications) for 16 months. She had no new trigeminal deficits after this procedure. The pain recurred, and she underwent repeat gamma knife radiosurgery targeting the distal trigeminal nerve using one 4-mm isocenter (maximum dose, 70 Gy). The pain continued to escalate until she required hospitalization for pain control and hydration. Three weeks after her second radiosurgical procedure, she underwent a repeat posterior fossa exploration. During that surgery, her trigeminal nerve was partially sectioned, and a small segment of the proximal to midcisternal nerve was sent for histological examination. There was no histologic evidence of nerve damage. Conclusion: This case supports the contention that trigeminal nerve injury is required to provide long lasting pain relief after trigeminal neuralgia radiosurgery.

Original languageEnglish (US)
Pages (from-to)655-658
Number of pages4
JournalSurgical Neurology
Volume68
Issue number6
DOIs
StatePublished - Dec 2007

Fingerprint

Trigeminal Nerve
Radiosurgery
Trigeminal Neuralgia
Pain
Trigeminal Nerve Injuries
Hospitalization

Keywords

  • Histology
  • Stereotactic radiosurgery
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Histologic analysis of a human trigeminal nerve after failed stereotactic radiosurgery : case report. / Foy, Andrew B.; Parisi, Joseph E; Pollock, Bruce E.

In: Surgical Neurology, Vol. 68, No. 6, 12.2007, p. 655-658.

Research output: Contribution to journalArticle

Foy, Andrew B. ; Parisi, Joseph E ; Pollock, Bruce E. / Histologic analysis of a human trigeminal nerve after failed stereotactic radiosurgery : case report. In: Surgical Neurology. 2007 ; Vol. 68, No. 6. pp. 655-658.
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