Histochemical, electron microscopic and electron histochemical studies of vacuoles and tubular structure in periodic paralysis (Japanese)

T. Santa, A. G. Engel

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Skeletal muscles from 2 cases of hyperkalemic periodic paralysis were studied by light microscopic histochemistry and electron microscopy including electron histochemistry. Histologically, the most prominent finding was vacuolization in the affected muscle fibers. Some vacuoles, though there was no evidence of the presence of the calcium in the vacuoles histochemically. Electron microscopic examination revealed that the vacuoles were occasionally connected with the t system and unusual aggregates of tubular structures were sometimes present in the subsarcolemmal area. The t system and most of the vacuoles were labeled with an electron cytochemical marker (horseradish peroxidase), and the final production of the Mg+ dependent enzyme reaction was demonstrated in the aggregates of small vacuoles and the sarcoplasmic reticulum by electron microscopy. On the basis of these observations, most of the vacuoles were considered to be derived from the t system and in addition the abnormal tubular aggregates were found to be proliferations of the sarcoplasmic reticulum. The pathogenesis of the morphologic changes is surveyed.

Original languageEnglish (US)
Pages (from-to)792-798
Number of pages7
JournalClinical Neurology
Issue number10
StatePublished - Jan 1 1974


ASJC Scopus subject areas

  • Clinical Neurology

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