TY - JOUR
T1 - Histiocytoid Sweet syndrome may indicate leukemia cutis
T2 - A novel application of fluorescence in situ hybridization
AU - Chavan, Rahul N.
AU - Cappel, Mark A.
AU - Ketterling, Rhett P.
AU - Wada, David A.
AU - Rochet, Nicole M.
AU - Knudson, Ryan
AU - Gibson, Lawrence E.
PY - 2014/6
Y1 - 2014/6
N2 - Background In patients with malignancy-associated Sweet syndrome, a thorough evaluation for leukemia cutis should be considered. Objective We sought to describe the clinicopathologic characteristics of histiocytoid Sweet syndrome. Methods We retrospectively identified patients with histiocytoid Sweet syndrome at our institution from January 1992 through December 2010. We evaluated the underlying cutaneous infiltrate using immunohistochemistry and fluorescence in situ hybridization. Results We re-evaluated all 22 patients with hematologic malignancy-associated Sweet syndrome. Six patients had a monocytoid infiltrate that was consistent with histiocytoid Sweet syndrome; subsequent evaluation of these patients demonstrated cytogenetic abnormalities on prior bone-marrow biopsy specimens. Fluorescence in situ hybridization analysis was feasible in cutaneous specimens from 5 of the 6 patients and demonstrated the same cytogenetic abnormalities that were identified on prior bone-marrow biopsy specimens in 4 patients. Therefore, these 4 patients may have had a form of leukemia cutis. Limitations This was a retrospective study. Conclusion For patients with histiocytoid Sweet syndrome, an underlying hematologic malignancy, and a monocytoid infiltrate on biopsy specimen, fluorescence in situ hybridization of the cutaneous infiltrate may be beneficial to identify cytogenetic abnormalities that may indicate leukemia cutis.
AB - Background In patients with malignancy-associated Sweet syndrome, a thorough evaluation for leukemia cutis should be considered. Objective We sought to describe the clinicopathologic characteristics of histiocytoid Sweet syndrome. Methods We retrospectively identified patients with histiocytoid Sweet syndrome at our institution from January 1992 through December 2010. We evaluated the underlying cutaneous infiltrate using immunohistochemistry and fluorescence in situ hybridization. Results We re-evaluated all 22 patients with hematologic malignancy-associated Sweet syndrome. Six patients had a monocytoid infiltrate that was consistent with histiocytoid Sweet syndrome; subsequent evaluation of these patients demonstrated cytogenetic abnormalities on prior bone-marrow biopsy specimens. Fluorescence in situ hybridization analysis was feasible in cutaneous specimens from 5 of the 6 patients and demonstrated the same cytogenetic abnormalities that were identified on prior bone-marrow biopsy specimens in 4 patients. Therefore, these 4 patients may have had a form of leukemia cutis. Limitations This was a retrospective study. Conclusion For patients with histiocytoid Sweet syndrome, an underlying hematologic malignancy, and a monocytoid infiltrate on biopsy specimen, fluorescence in situ hybridization of the cutaneous infiltrate may be beneficial to identify cytogenetic abnormalities that may indicate leukemia cutis.
KW - Sweet syndrome
KW - cytogenetic abnormalities
KW - fluorescence in situ hybridization analysis
KW - histiocytoid Sweet syndrome
KW - leukemia cutis
KW - malignancy-associated Sweet syndrome
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U2 - 10.1016/j.jaad.2014.01.874
DO - 10.1016/j.jaad.2014.01.874
M3 - Article
C2 - 24636890
AN - SCOPUS:84901197541
SN - 0190-9622
VL - 70
SP - 1021
EP - 1027
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -