Histiocytic lesions and proliferations in the lung

Chih wei Wang, Thomas V. Colby

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Pulmonary lesions encountered by the pathologist in which histiocytes are the dominant finding histologically are reviewed. Lesions discussed include neoplasms of histiocytes and nonneoplastic processes. The nonneoplastic processes are divided into those that present as nodular histiocytic proliferations in the lung, those that present as diffuse proliferations of histiocytes in the lung, and those with a mixed pattern. Entities discussed include pulmonary Langerhans' cell histiocytosis, pneumonoconioses, infections, diffuse panbronchiolitis, crystal storing histiocytosis, respiratory bronchiolitis, alveolar hemorrhage, eosinophilic pneumonia, obstructive pneumonia, exogenous lipoid pneumonia, some drug reactions, and some metabolic/storage diseases. Entities of uncertain histogenesis, including Rosai-Dorfman disease and Erdheim-Chester disease, are also discussed. Qualitative features of the histiocytes are addressed, including the presence of foreign dust, hemosiderin, foamy change, and histiocytes showing features of Langerhans' cells.

Original languageEnglish (US)
Pages (from-to)162-182
Number of pages21
JournalSeminars in Diagnostic Pathology
Volume24
Issue number3
DOIs
StatePublished - Aug 2007

Fingerprint

Histiocytes
Lung
Pneumonia
Erdheim-Chester Disease
Sinus Histiocytosis
Histiocytosis
Pulmonary Eosinophilia
Hemosiderin
Langerhans Cell Histiocytosis
Bronchiolitis
Langerhans Cells
Metabolic Diseases
Dust
Hemorrhage
Infection
Pharmaceutical Preparations
Neoplasms

Keywords

  • Histiocytes
  • Lung
  • Macrophages
  • Neoplasms
  • Pathology
  • Pneumoconioses

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Histiocytic lesions and proliferations in the lung. / Wang, Chih wei; Colby, Thomas V.

In: Seminars in Diagnostic Pathology, Vol. 24, No. 3, 08.2007, p. 162-182.

Research output: Contribution to journalArticle

Wang, Chih wei ; Colby, Thomas V. / Histiocytic lesions and proliferations in the lung. In: Seminars in Diagnostic Pathology. 2007 ; Vol. 24, No. 3. pp. 162-182.
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