Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases

Fabio Facchetti, Stefano Aldo Pileri, Luisa Lorenzi, Valentina Tabanelli, Lisa Rimsza, Stefania Pittaluga, Stephan Dirnhofer, Christiane Copie-Bergman, Laurence de Leval, Andreas Rosenwald, Andrew Wotherspoon, Falko Fend

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Tumors derived from histiocytic and dendritic cells encompass a large and heterogeneous group of neoplastic and reactive conditions, and their diagnosis is challenging both for pathologists and clinicians. Diagnosis is based on morphological and phenotypical findings, but hybrid features are not uncommon. Furthermore, recent studies uncovered the molecular mechanisms driving some of these tumors, improving diagnostic adequacy, and providing the basis for effective therapeutic breakthroughs. Sixty-seven cases were submitted to the accessory cell and histiocytic neoplasms session at the European Association of Haematopathology/Society for Hematopathology workshop 2016 held in Basel, Switzerland. The cases included histiocytic sarcomas (HS), Langerhans cell tumors (LCT), Erdheim-Chester disease, interdigitating dendritic cell sarcomas (IDCS), indeterminate dendritic cell tumors (IND-DCT), follicular dendritic cell sarcomas, and blastic plasmacytoid dendritic cell neoplasms. Rosai-Dorfman disease and, more rare, conditions such as ALK-positive histiocytosis were also submitted. These cases illustrated classical and unexpected features at morphological, phenotypical, and molecular levels, providing a valuable compendium for pathologists confronting with these tumors. The paper summarizes the most notable features of every single group of diseases, with comments about the most challenging issues, in the attempt to provide practical indications for their recognition.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalVirchows Archiv
DOIs
StateAccepted/In press - Jul 10 2017

Fingerprint

Dendritic Cells
Neoplasms
Interdigitating Dendritic Cell Sarcoma
Follicular Dendritic Cell Sarcoma
Erdheim-Chester Disease
Sinus Histiocytosis
Histiocytic Sarcoma
Histiocytosis
Langerhans Cells
Switzerland
Education

Keywords

  • Dendritic cells
  • Histiocytes
  • Neoplasms
  • Tumors

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Facchetti, F., Pileri, S. A., Lorenzi, L., Tabanelli, V., Rimsza, L., Pittaluga, S., ... Fend, F. (Accepted/In press). Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases. Virchows Archiv, 1-23. https://doi.org/10.1007/s00428-017-2176-1

Histiocytic and dendritic cell neoplasms : what have we learnt by studying 67 cases. / Facchetti, Fabio; Pileri, Stefano Aldo; Lorenzi, Luisa; Tabanelli, Valentina; Rimsza, Lisa; Pittaluga, Stefania; Dirnhofer, Stephan; Copie-Bergman, Christiane; de Leval, Laurence; Rosenwald, Andreas; Wotherspoon, Andrew; Fend, Falko.

In: Virchows Archiv, 10.07.2017, p. 1-23.

Research output: Contribution to journalArticle

Facchetti, F, Pileri, SA, Lorenzi, L, Tabanelli, V, Rimsza, L, Pittaluga, S, Dirnhofer, S, Copie-Bergman, C, de Leval, L, Rosenwald, A, Wotherspoon, A & Fend, F 2017, 'Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases' Virchows Archiv, pp. 1-23. https://doi.org/10.1007/s00428-017-2176-1
Facchetti, Fabio ; Pileri, Stefano Aldo ; Lorenzi, Luisa ; Tabanelli, Valentina ; Rimsza, Lisa ; Pittaluga, Stefania ; Dirnhofer, Stephan ; Copie-Bergman, Christiane ; de Leval, Laurence ; Rosenwald, Andreas ; Wotherspoon, Andrew ; Fend, Falko. / Histiocytic and dendritic cell neoplasms : what have we learnt by studying 67 cases. In: Virchows Archiv. 2017 ; pp. 1-23.
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