TY - JOUR
T1 - Histiocytes containing immunoglobulin crystals in the urine of a patient with IgA κ plasmacytoma of the bladder
AU - Miller, Dylan V.
AU - McClure, Rebecca F.
AU - Crawford, Barbara G.
AU - Zeldenrust, Steven R.
AU - Leibovich, Bradley C.
AU - Sebo, Thomas J.
PY - 2004/7
Y1 - 2004/7
N2 - Exfoliative cytology specimens from patients with plasma cell dyscrasias are rarely diagnostic, though there are reports of neoplastic plasma cells observed in pleural fluid and urine. Immunoglobulin concretions or crystals associated with neoplastic plasma cell populations have been well described. These crystals may be found within plasma cell nuclei or cytoplasm, extracellularly, or within cells of histiocytic lineage where they are presumably derived by phagocytosis. To the best of our knowledge, this is the first report of immunoglobulin crystals within histiocytes in the urine of a patient with plasmacytoma. A 61-year-old male underwent routine cystoscopy and urine collection to evaluate hematuria. The bladder biopsy demonstrated IgA κ-producing plasmacytoma. Urine cytopsin preparations did not contain plasma cells, but there were histiocytic cells with degenerative nuclei and eccentrically located cytoplasmic spherical refractile hyaline crystals thought to be immunoglobulin crystals. This was supported by immunocytochemical staining.
AB - Exfoliative cytology specimens from patients with plasma cell dyscrasias are rarely diagnostic, though there are reports of neoplastic plasma cells observed in pleural fluid and urine. Immunoglobulin concretions or crystals associated with neoplastic plasma cell populations have been well described. These crystals may be found within plasma cell nuclei or cytoplasm, extracellularly, or within cells of histiocytic lineage where they are presumably derived by phagocytosis. To the best of our knowledge, this is the first report of immunoglobulin crystals within histiocytes in the urine of a patient with plasmacytoma. A 61-year-old male underwent routine cystoscopy and urine collection to evaluate hematuria. The bladder biopsy demonstrated IgA κ-producing plasmacytoma. Urine cytopsin preparations did not contain plasma cells, but there were histiocytic cells with degenerative nuclei and eccentrically located cytoplasmic spherical refractile hyaline crystals thought to be immunoglobulin crystals. This was supported by immunocytochemical staining.
KW - Exfoliative cytology
KW - Immunoglobulin crystals
KW - Plasmocytic neoplasia
KW - Urine
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U2 - 10.1002/dc.20083
DO - 10.1002/dc.20083
M3 - Article
C2 - 15236265
AN - SCOPUS:3042789128
SN - 8755-1039
VL - 31
SP - 48
EP - 51
JO - Diagnostic cytopathology
JF - Diagnostic cytopathology
IS - 1
ER -