Histamine H1 receptors in the brain and spinal cord of the cat

John E. Taylor, Tony L. Yaksh, Elliott Richelson

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The regional distribution of histamine H1 receptors in the feline brain and spinal cord was determined in vitro using the radio-actively labeled histamine H1 antagonist, [3H]pyrilamine. This distribution of H1 receptors, which was different from that reported for other species, was highest in the hypothalamus and mammillary bodies. Intermediate levels of binding were observed in the cerebral cortical and limbic regions, corpus striatum, colliculi, cerebellum, and medulla. The lowest binding was found in the pons and spinal cord. Binding in the spinal cord was concentrated in the gray matter, but the number of binding sites detected in the dorsal and ventral horns did not differ. The equilibrium dissociation constants for [3H]pyrilamine were similar for the various regions and were in the range of 2-3 nM and the pharmacological characteristics of the feline brain and spinal H1 receptors were similar to those found in the brains of other mammalian species with the exception of the guinea pig.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalBrain Research
Volume243
Issue number2
DOIs
StatePublished - Jul 15 1982

Keywords

  • cat
  • H receptors
  • histamine H

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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