Histamine H₁ receptor-mediated guanosine 3′,5′- monophosphate formation by cultured mouse neuroblastoma cells

Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3′,5′- monophosphate (cyclic GMP) by these cells. Receptor agonists for H₁, but not H₂, caused this effect which was reduced by H₁ but not by H₂ or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H₁ receptors in these cultured nerve cells stimulated cyclic GMP formation.