Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To predict the risk of probable dementia with Lewy bodies (DLB) competing with Alzheimer disease (AD) dementia by hippocampal volume (HV) in patients with mild cognitive impairment (MCI) with impairments in amnestic or nonamnestic cognitive domains. Methods: Patients with MCI (n = 160) from the Mayo Clinic Alzheimer's Disease Research Center, who participated in an MRI study at baseline from 2005 to 2014, were followed with approximately annual clinical evaluations. HVs were analyzed from 3T MRIs using FreeSurfer (5.3). Hippocampal atrophy was determined from the most normal 10th percentile of the measurement distributions in a separate cohort of clinically diagnosed patients with AD dementia. The subdistribution hazard ratios for progression to probable DLB and AD dementia were estimated by taking into account the competing risks. Results: During a median (range) follow-up of 2.0 (0.7-8.1) years, 20 (13%) patients with MCI progressed to probable DLB, and 61 (38%) progressed to AD dementia. The estimated subdistribution hazard ratio (95% confidence interval) for normal HV relative to hippocampal atrophy for progression to AD dementia was 0.56 (0.34-0.91; p = 0.02) after taking into account the competing risks. The estimated hazard ratio for normal HV relative to hippocampal atrophy for progression to probable DLB was 4.22 (1.42-12.6; p = 0.01) after adjusting for age and after including the MCI subtype in the model. Conclusions: Preserved hippocampal volumes are associated with increased risk of probable DLB competing with AD dementia in patients with MCI. Preservation of HV may support prodromal DLB over AD, particularly in patients with MCI with nonamnestic features.

Original languageEnglish (US)
Pages (from-to)2317-2323
Number of pages7
JournalNeurology
Volume87
Issue number22
DOIs
StatePublished - Nov 29 2016

Fingerprint

Lewy Body Disease
Alzheimer Disease
Atrophy
Cognitive Dysfunction

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment. / Kantarci, Kejal M; Lesnick, Timothy; Ferman, Tanis Jill; Przybelski, Scott A.; Boeve, Bradley F; Smith, Glenn E.; Kremers, Walter K; Knopman, David S; Jack, Clifford R Jr.; Petersen, Ronald Carl.

In: Neurology, Vol. 87, No. 22, 29.11.2016, p. 2317-2323.

Research output: Contribution to journalArticle

@article{ad2f592dd4d84b2db7651563936aeafe,
title = "Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment",
abstract = "Objective: To predict the risk of probable dementia with Lewy bodies (DLB) competing with Alzheimer disease (AD) dementia by hippocampal volume (HV) in patients with mild cognitive impairment (MCI) with impairments in amnestic or nonamnestic cognitive domains. Methods: Patients with MCI (n = 160) from the Mayo Clinic Alzheimer's Disease Research Center, who participated in an MRI study at baseline from 2005 to 2014, were followed with approximately annual clinical evaluations. HVs were analyzed from 3T MRIs using FreeSurfer (5.3). Hippocampal atrophy was determined from the most normal 10th percentile of the measurement distributions in a separate cohort of clinically diagnosed patients with AD dementia. The subdistribution hazard ratios for progression to probable DLB and AD dementia were estimated by taking into account the competing risks. Results: During a median (range) follow-up of 2.0 (0.7-8.1) years, 20 (13{\%}) patients with MCI progressed to probable DLB, and 61 (38{\%}) progressed to AD dementia. The estimated subdistribution hazard ratio (95{\%} confidence interval) for normal HV relative to hippocampal atrophy for progression to AD dementia was 0.56 (0.34-0.91; p = 0.02) after taking into account the competing risks. The estimated hazard ratio for normal HV relative to hippocampal atrophy for progression to probable DLB was 4.22 (1.42-12.6; p = 0.01) after adjusting for age and after including the MCI subtype in the model. Conclusions: Preserved hippocampal volumes are associated with increased risk of probable DLB competing with AD dementia in patients with MCI. Preservation of HV may support prodromal DLB over AD, particularly in patients with MCI with nonamnestic features.",
author = "Kantarci, {Kejal M} and Timothy Lesnick and Ferman, {Tanis Jill} and Przybelski, {Scott A.} and Boeve, {Bradley F} and Smith, {Glenn E.} and Kremers, {Walter K} and Knopman, {David S} and Jack, {Clifford R Jr.} and Petersen, {Ronald Carl}",
year = "2016",
month = "11",
day = "29",
doi = "10.1212/WNL.0000000000003371",
language = "English (US)",
volume = "87",
pages = "2317--2323",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "22",

}

TY - JOUR

T1 - Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment

AU - Kantarci, Kejal M

AU - Lesnick, Timothy

AU - Ferman, Tanis Jill

AU - Przybelski, Scott A.

AU - Boeve, Bradley F

AU - Smith, Glenn E.

AU - Kremers, Walter K

AU - Knopman, David S

AU - Jack, Clifford R Jr.

AU - Petersen, Ronald Carl

PY - 2016/11/29

Y1 - 2016/11/29

N2 - Objective: To predict the risk of probable dementia with Lewy bodies (DLB) competing with Alzheimer disease (AD) dementia by hippocampal volume (HV) in patients with mild cognitive impairment (MCI) with impairments in amnestic or nonamnestic cognitive domains. Methods: Patients with MCI (n = 160) from the Mayo Clinic Alzheimer's Disease Research Center, who participated in an MRI study at baseline from 2005 to 2014, were followed with approximately annual clinical evaluations. HVs were analyzed from 3T MRIs using FreeSurfer (5.3). Hippocampal atrophy was determined from the most normal 10th percentile of the measurement distributions in a separate cohort of clinically diagnosed patients with AD dementia. The subdistribution hazard ratios for progression to probable DLB and AD dementia were estimated by taking into account the competing risks. Results: During a median (range) follow-up of 2.0 (0.7-8.1) years, 20 (13%) patients with MCI progressed to probable DLB, and 61 (38%) progressed to AD dementia. The estimated subdistribution hazard ratio (95% confidence interval) for normal HV relative to hippocampal atrophy for progression to AD dementia was 0.56 (0.34-0.91; p = 0.02) after taking into account the competing risks. The estimated hazard ratio for normal HV relative to hippocampal atrophy for progression to probable DLB was 4.22 (1.42-12.6; p = 0.01) after adjusting for age and after including the MCI subtype in the model. Conclusions: Preserved hippocampal volumes are associated with increased risk of probable DLB competing with AD dementia in patients with MCI. Preservation of HV may support prodromal DLB over AD, particularly in patients with MCI with nonamnestic features.

AB - Objective: To predict the risk of probable dementia with Lewy bodies (DLB) competing with Alzheimer disease (AD) dementia by hippocampal volume (HV) in patients with mild cognitive impairment (MCI) with impairments in amnestic or nonamnestic cognitive domains. Methods: Patients with MCI (n = 160) from the Mayo Clinic Alzheimer's Disease Research Center, who participated in an MRI study at baseline from 2005 to 2014, were followed with approximately annual clinical evaluations. HVs were analyzed from 3T MRIs using FreeSurfer (5.3). Hippocampal atrophy was determined from the most normal 10th percentile of the measurement distributions in a separate cohort of clinically diagnosed patients with AD dementia. The subdistribution hazard ratios for progression to probable DLB and AD dementia were estimated by taking into account the competing risks. Results: During a median (range) follow-up of 2.0 (0.7-8.1) years, 20 (13%) patients with MCI progressed to probable DLB, and 61 (38%) progressed to AD dementia. The estimated subdistribution hazard ratio (95% confidence interval) for normal HV relative to hippocampal atrophy for progression to AD dementia was 0.56 (0.34-0.91; p = 0.02) after taking into account the competing risks. The estimated hazard ratio for normal HV relative to hippocampal atrophy for progression to probable DLB was 4.22 (1.42-12.6; p = 0.01) after adjusting for age and after including the MCI subtype in the model. Conclusions: Preserved hippocampal volumes are associated with increased risk of probable DLB competing with AD dementia in patients with MCI. Preservation of HV may support prodromal DLB over AD, particularly in patients with MCI with nonamnestic features.

UR - http://www.scopus.com/inward/record.url?scp=84999836825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84999836825&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000003371

DO - 10.1212/WNL.0000000000003371

M3 - Article

C2 - 27807186

AN - SCOPUS:84999836825

VL - 87

SP - 2317

EP - 2323

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 22

ER -