Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection

Charles L Howe, Reghann G. Lafrance-Corey, Rhianna S. Sundsbak, Brian M. Sauer, Stephanie J. Lafrance, Eric J. Buenz, William F. Schmalstieg

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Neuronal injury during acute viral infection of the brain is associated with the development of persistent cognitive deficits and seizures in humans. In C57BL/6 mice acutely infected with the Theiler's murine encephalomyelitis virus, hippocampal CA1 neurons are injured by a rapid innate immune response, resulting in profound memory deficits. In contrast, infected SJL and B6xSJL F1 hybrid mice exhibit essentially complete hippocampal and memory preservation. Analysis of brain-infiltrating leukocytes revealed that SJL mice mount a sharply attenuated inflammatory monocyte response as compared to B6 mice. Bone marrow transplantation experiments isolated the attenuation to the SJL immune system. Adoptive transfer of B6 inflammatory monocytes into acutely infected B6xSJL hosts converted these mice to a hippocampal damage phenotype and induced a cognitive deficit marked by failure to recognize a novel object. These findings show that inflammatory monocytes are the critical cellular mediator of hippocampal injury during acute picornavirus infection of the brain.

Original languageEnglish (US)
Article number545
JournalScientific Reports
Volume2
DOIs
StatePublished - 2012

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Picornaviridae Infections
Monocytes
Brain
Theilovirus
Adoptive Transfer
Memory Disorders
Wounds and Injuries
Virus Diseases
Bone Marrow Transplantation
Inbred C57BL Mouse
Innate Immunity
Immune System
Seizures
Leukocytes
Phenotype
Neurons

ASJC Scopus subject areas

  • General

Cite this

Howe, C. L., Lafrance-Corey, R. G., Sundsbak, R. S., Sauer, B. M., Lafrance, S. J., Buenz, E. J., & Schmalstieg, W. F. (2012). Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection. Scientific Reports, 2, [545]. https://doi.org/10.1038/srep00545

Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection. / Howe, Charles L; Lafrance-Corey, Reghann G.; Sundsbak, Rhianna S.; Sauer, Brian M.; Lafrance, Stephanie J.; Buenz, Eric J.; Schmalstieg, William F.

In: Scientific Reports, Vol. 2, 545, 2012.

Research output: Contribution to journalArticle

Howe, Charles L ; Lafrance-Corey, Reghann G. ; Sundsbak, Rhianna S. ; Sauer, Brian M. ; Lafrance, Stephanie J. ; Buenz, Eric J. ; Schmalstieg, William F. / Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection. In: Scientific Reports. 2012 ; Vol. 2.
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