HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription

Partha Mitra, Ronglin Xie, J. Wade Harper, Janet L. Stein, Gary S. Stein, Andre J van Wijnen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cell cycle progression beyond the G1/S phase transition requires the activation of a transcription complex containing histone nuclear factor P (HiNF-P) and nuclear protein mapped to ataxia telangiectasia (p220 NPAT) in response to cyclin dependent kinase 2 (CDK2)/cyclin E signaling. We show here that the potent co-activating properties of HiNF-P/p220NPAT on the histone H4 gene promoter, which are evident in the majority of human cell types, are sporadically neutralized in distinct somatic cell lines. In cells where HiNF-P and p220NPAT do not activate the H4 gene promoter, HiNF-P instead represses transcription. Our data suggest that the cell type specific expression of the cyclin-dependent kinase inhibitory (CKI) protein p57KIP2 inhibits the HiNF-P dependent activation of the histone H4 promoter. We propose that, analogous to E2F proteins and other cell cycle regulatory proteins, HiNF-P is a bifunctional transcriptional regulator that can activate or repress cell cycle controlled genes depending on the cellular context.

Original languageEnglish (US)
Pages (from-to)181-191
Number of pages11
JournalJournal of Cellular Biochemistry
Volume101
Issue number1
DOIs
StatePublished - May 1 2007
Externally publishedYes

Fingerprint

Transcription
Histones
Cell Cycle
Genes
Cells
Cyclin-Dependent Kinase Inhibitor p57
Chemical activation
E2F Transcription Factors
Cyclin-Dependent Kinase 2
cdc Genes
Cyclin E
Ataxia Telangiectasia
Cell Cycle Proteins
Cyclin-Dependent Kinases
Phase Transition
G1 Phase
Nuclear Proteins
S Phase
Transcriptional Activation
Phase transitions

Keywords

  • CDK inhibitor
  • Cell cycle
  • HiNF-P
  • Histone
  • KIP2
  • NPAT
  • p57
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Mitra, P., Xie, R., Harper, J. W., Stein, J. L., Stein, G. S., & van Wijnen, A. J. (2007). HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. Journal of Cellular Biochemistry, 101(1), 181-191. https://doi.org/10.1002/jcb.21157

HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. / Mitra, Partha; Xie, Ronglin; Harper, J. Wade; Stein, Janet L.; Stein, Gary S.; van Wijnen, Andre J.

In: Journal of Cellular Biochemistry, Vol. 101, No. 1, 01.05.2007, p. 181-191.

Research output: Contribution to journalArticle

Mitra, P, Xie, R, Harper, JW, Stein, JL, Stein, GS & van Wijnen, AJ 2007, 'HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription', Journal of Cellular Biochemistry, vol. 101, no. 1, pp. 181-191. https://doi.org/10.1002/jcb.21157
Mitra, Partha ; Xie, Ronglin ; Harper, J. Wade ; Stein, Janet L. ; Stein, Gary S. ; van Wijnen, Andre J. / HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. In: Journal of Cellular Biochemistry. 2007 ; Vol. 101, No. 1. pp. 181-191.
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