Highly polymorphic DNA sequences in the distal region of the long arm of human chromosome 18

U. Müller, T. A. Donlon, Peter C Harris, E. Rose, E. Hoffman, G. P. Bruns, S. A. Latt

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Highly polymorphic repeated DNA sequences were detected at the end of the long arm of human chromosome 18 by a recombinant DNA probe containing 56 bp of human DNA (pERT25). This was shown by hybridization of pERT25 to DNA from a panel of human × rodent somatic cell hybrids, by dot blot hybridization to flow-sorted human chromosomes, and by in situ hybridization to metaphase chromosomes. The high degree of polymorphism detected by this 18q DNA fragment makes it potentially useful for various applications, including investigations into the genetics of trisomy 18 (Edwards syndrome), linkage studies, and paternity testing.

Original languageEnglish (US)
Pages (from-to)16-20
Number of pages5
JournalCytogenetic and Genome Research
Volume45
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 18
Human Chromosomes
DNA
Paternity
Recombinant DNA
Hybrid Cells
DNA Probes
Metaphase
In Situ Hybridization
Rodentia
Chromosomes
Trisomy 18

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

Highly polymorphic DNA sequences in the distal region of the long arm of human chromosome 18. / Müller, U.; Donlon, T. A.; Harris, Peter C; Rose, E.; Hoffman, E.; Bruns, G. P.; Latt, S. A.

In: Cytogenetic and Genome Research, Vol. 45, No. 1, 1987, p. 16-20.

Research output: Contribution to journalArticle

Müller, U. ; Donlon, T. A. ; Harris, Peter C ; Rose, E. ; Hoffman, E. ; Bruns, G. P. ; Latt, S. A. / Highly polymorphic DNA sequences in the distal region of the long arm of human chromosome 18. In: Cytogenetic and Genome Research. 1987 ; Vol. 45, No. 1. pp. 16-20.
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