Higher-Resolution Magnetic Resonance Elastography in Meningiomas to Determine Intratumoral Consistency

Joshua D. Hughes, Nikoo Fattahi, J. Van Gompel, Arvin Arani, Fredric Meyer, Giuseppe Lanzino, Michael J. Link, Richard Ehman, John Huston

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

BACKGROUND: Magnetic resonance elastography (MRE) analyzes shear wave movement through tissue to determine stiffness. In a prior study, measurements with first-generation brain MRE techniques correlated with intraoperative observations of overall meningioma stiffness. OBJECTIVE: To evaluate the diagnostic accuracy of a higher-resolution MRE technique to preoperatively detect intratumoral variations compared with surgeon assessment. METHODS: Fifteen meningiomas in 14 patients underwent MRE. Tumors with regions of distinctly different stiffness were considered heterogeneous. Intratumoral portions were considered hard if there was a significant area ≥6 kPa. A 5-point scale graded intraoperative consistency. A durometer semiquantitatively measured surgical specimen hardness. Statistics included χ 2, sensitivity, specificity, positive and negative predicative values, and Spearman rank correlation coefficient. RESULTS: For MRE and surgery, 9 (60%) and 7 (47%) tumors were homogeneous, 6 (40%) and 8 (53%) tumors were heterogeneous, 6 (40%) and 10 (67%) tumors had hard portions, and 14 (93%) and 12 (80%) tumors had soft portions, respectively. MRE sensitivity, specificity, and positive and negative predictive values were as follows: for heterogeneity, 75%, 100%, 100%, and 87%; for hardness, 60%, 100%, 100%, and 56%; and for softness, 100%, 33%, 86%, and 100%. Overall, 10 tumors (67%) matched well with MRE and intraoperative consistency and correlated between intraoperative observations (P .02) and durometer readings (P .03). Tumor size ≤3.5 cm or vascular tumors were more likely to be inconsistent (P <.05). CONCLUSION: MRE was excellent at ruling in heterogeneity with hard portions but less effective in ruling out heterogeneity and hard portions, particularly in tumors more vascular or <3.5 cm. MRE is the first technology capable of prospectively evaluating intratumoral stiffness and, with further refinement, will likely prove useful in preoperative planning. ABBREVIATIONS: MRE, magnetic resonance elastography NPV, negative predictive value PPV, positive predictive value ROI, region of interest .

Original languageEnglish (US)
Pages (from-to)653-658
Number of pages6
JournalNeurosurgery
Volume77
Issue number4
DOIs
StatePublished - Oct 21 2015

Keywords

  • Consistency
  • MRE
  • Magnetic resonance elastography
  • Meningioma
  • Stiffness

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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