Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer

A. J. Fritz, N. E. Gillis, D. L. Gerrard, P. D. Rodriguez, D. Hong, J. T. Rose, P. N. Ghule, E. L. Bolf, J. A. Gordon, C. E. Tye, J. R. Boyd, K. M. Tracy, J. A. Nickerson, A. J. van Wijnen, A. N. Imbalzano, J. L. Heath, S. E. Frietze, S. K. Zaidi, F. E. Carr, J. B. LianJ. L. Stein, G. S. Stein

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone modifications and higher order chromatin organization (HCO) that are perturbed in breast cancer onset and progression. Implications for dysfunctions that occur in hormone regulation, cell cycle control, and mitotic bookmarking in breast cancer are considered, with an emphasis on epithelial-to-mesenchymal transition and cancer stem cell activities. The architectural organization of regulatory machinery is addressed within the contexts of translating cancer-compromised genomic organization to advances in breast cancer risk assessment, diagnosis, prognosis, and identification of novel therapeutic targets with high specificity and minimal off target effects.

Original languageEnglish (US)
Pages (from-to)484-499
Number of pages16
JournalGenes Chromosomes and Cancer
Volume58
Issue number7
DOIs
StatePublished - Jul 2019

Keywords

  • RUNX
  • breast cancer
  • cancer stem cells
  • epithelial to mesenchymal transition
  • higher order chromatin organization
  • hormone regulation
  • mitotic bookmarking

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer'. Together they form a unique fingerprint.

  • Cite this

    Fritz, A. J., Gillis, N. E., Gerrard, D. L., Rodriguez, P. D., Hong, D., Rose, J. T., Ghule, P. N., Bolf, E. L., Gordon, J. A., Tye, C. E., Boyd, J. R., Tracy, K. M., Nickerson, J. A., van Wijnen, A. J., Imbalzano, A. N., Heath, J. L., Frietze, S. E., Zaidi, S. K., Carr, F. E., ... Stein, G. S. (2019). Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer. Genes Chromosomes and Cancer, 58(7), 484-499. https://doi.org/10.1002/gcc.22731