High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

Jörg J. Goronzy; Qian Qi; Richard A. Olshen; Cornelia M. Weyand

doi:10.1186/s13073-015-0242-3

High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

Jörg J. Goronzy, Qian Qi, Richard A. Olshen, Cornelia M. Weyand

Immunology

Research output: Contribution to journal › Comment/debate › peer-review

18 Scopus citations

Abstract

Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.

Original language	English (US)
Article number	117
Journal	Genome medicine
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/s13073-015-0242-3
State	Published - Nov 19 2015

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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10.1186/s13073-015-0242-3

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abstract = "Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.",

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AB - Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.

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High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

Abstract

ASJC Scopus subject areas

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