High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

Jörg J. Goronzy, Qian Qi, Richard A. Olshen, Cornelia M. Weyand

Research output: Contribution to journalComment/debatepeer-review

18 Scopus citations

Abstract

Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.

Original languageEnglish (US)
Article number117
JournalGenome medicine
Volume7
Issue number1
DOIs
StatePublished - Nov 19 2015

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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