High-throughput processing to preserve viable cells: A precision medicine initiative cohort program workshop

Rebekah S. Rasooly, Daniel R. Gossett, Marianne K. Henderson, Allison Hubel, Stephen N Thibodeau

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Conventionally, biobanks supporting clinical research studies have preserved serum, plasma, urine, saliva, a variety of tissue types, and stool. With the emergence of increasingly sophisticated technologies for analyzing single cells, there is growing interest in preserving viable blood cells for future functional studies. The new All of Us Research Program (formerly the Precision Medicine Initiative Cohort Program) biobank plans to house samples from a million or more individuals as part of a cohort with rich phenotypic data and longitudinal follow-up (www.nih.gov/research-training/allofus-research-program). Storage of viable cells for future single-cell analysis offers the promise of new biology, discovery of novel biomarkers, and advances toward the goal of precision medicine. A workshop was held in the summer of 2016 to evaluate the case for preservation of viable mononuclear blood cells and its feasibility within the collection plan for the biobank.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalBiopreservation and Biobanking
Volume15
Issue number4
DOIs
StatePublished - Aug 1 2017

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Keywords

  • biomarkers
  • cell preservation
  • cell viability
  • high-throughput
  • precision medicine
  • single-cell analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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