High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus

T. B. Niewold, J. Hua, T. J A Lehman, J. B. Harley, M. K. Crow

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

Interferon α (IFN-α) levels are elevated in many patients with systemic lupus erythematosus (SLE); however it is not known whether high serum IFN-α activity is a cause or a result of the disease. We studied 266 SLE patients and 405 of their healthy relatives, and frequently found high serum IFN-α activity in both patients and healthy relatives as compared to healthy unrelated individuals. High IFN-α activity was clustered in specific families in both SLE patients and their healthy first-degree relatives, suggesting a heritable trait. Heritability was also supported by quantitative familial correlation of IFN-α activity, concordance in affected sib pairs and frequent transmission of the high IFN-α activity trait from parents to offspring. Autoantibodies to RNA-binding proteins and double-stranded DNA were associated with high IFN-α activity in SLE patients; however these autoantibodies were very uncommon in healthy family members and did not explain the observed familial correlations. The frequency of high IFN-α activity was similar across all studied ethnic backgrounds. These data suggest that high serum IFN-α activity is a complex heritable trait, which plays a primary role in SLE pathogenesis.

Original languageEnglish (US)
Pages (from-to)492-502
Number of pages11
JournalGenes and Immunity
Volume8
Issue number6
DOIs
StatePublished - Sep 2007
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Serum
Autoantibodies
RNA-Binding Proteins
Interferons
Parents
DNA

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Niewold, T. B., Hua, J., Lehman, T. J. A., Harley, J. B., & Crow, M. K. (2007). High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus. Genes and Immunity, 8(6), 492-502. https://doi.org/10.1038/sj.gene.6364408

High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus. / Niewold, T. B.; Hua, J.; Lehman, T. J A; Harley, J. B.; Crow, M. K.

In: Genes and Immunity, Vol. 8, No. 6, 09.2007, p. 492-502.

Research output: Contribution to journalArticle

Niewold, TB, Hua, J, Lehman, TJA, Harley, JB & Crow, MK 2007, 'High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus', Genes and Immunity, vol. 8, no. 6, pp. 492-502. https://doi.org/10.1038/sj.gene.6364408
Niewold, T. B. ; Hua, J. ; Lehman, T. J A ; Harley, J. B. ; Crow, M. K. / High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus. In: Genes and Immunity. 2007 ; Vol. 8, No. 6. pp. 492-502.
@article{99caa953fd2545759ee233c7c4056a7f,
title = "High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus",
abstract = "Interferon α (IFN-α) levels are elevated in many patients with systemic lupus erythematosus (SLE); however it is not known whether high serum IFN-α activity is a cause or a result of the disease. We studied 266 SLE patients and 405 of their healthy relatives, and frequently found high serum IFN-α activity in both patients and healthy relatives as compared to healthy unrelated individuals. High IFN-α activity was clustered in specific families in both SLE patients and their healthy first-degree relatives, suggesting a heritable trait. Heritability was also supported by quantitative familial correlation of IFN-α activity, concordance in affected sib pairs and frequent transmission of the high IFN-α activity trait from parents to offspring. Autoantibodies to RNA-binding proteins and double-stranded DNA were associated with high IFN-α activity in SLE patients; however these autoantibodies were very uncommon in healthy family members and did not explain the observed familial correlations. The frequency of high IFN-α activity was similar across all studied ethnic backgrounds. These data suggest that high serum IFN-α activity is a complex heritable trait, which plays a primary role in SLE pathogenesis.",
author = "Niewold, {T. B.} and J. Hua and Lehman, {T. J A} and Harley, {J. B.} and Crow, {M. K.}",
year = "2007",
month = "9",
doi = "10.1038/sj.gene.6364408",
language = "English (US)",
volume = "8",
pages = "492--502",
journal = "Genes and Immunity",
issn = "1466-4879",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus

AU - Niewold, T. B.

AU - Hua, J.

AU - Lehman, T. J A

AU - Harley, J. B.

AU - Crow, M. K.

PY - 2007/9

Y1 - 2007/9

N2 - Interferon α (IFN-α) levels are elevated in many patients with systemic lupus erythematosus (SLE); however it is not known whether high serum IFN-α activity is a cause or a result of the disease. We studied 266 SLE patients and 405 of their healthy relatives, and frequently found high serum IFN-α activity in both patients and healthy relatives as compared to healthy unrelated individuals. High IFN-α activity was clustered in specific families in both SLE patients and their healthy first-degree relatives, suggesting a heritable trait. Heritability was also supported by quantitative familial correlation of IFN-α activity, concordance in affected sib pairs and frequent transmission of the high IFN-α activity trait from parents to offspring. Autoantibodies to RNA-binding proteins and double-stranded DNA were associated with high IFN-α activity in SLE patients; however these autoantibodies were very uncommon in healthy family members and did not explain the observed familial correlations. The frequency of high IFN-α activity was similar across all studied ethnic backgrounds. These data suggest that high serum IFN-α activity is a complex heritable trait, which plays a primary role in SLE pathogenesis.

AB - Interferon α (IFN-α) levels are elevated in many patients with systemic lupus erythematosus (SLE); however it is not known whether high serum IFN-α activity is a cause or a result of the disease. We studied 266 SLE patients and 405 of their healthy relatives, and frequently found high serum IFN-α activity in both patients and healthy relatives as compared to healthy unrelated individuals. High IFN-α activity was clustered in specific families in both SLE patients and their healthy first-degree relatives, suggesting a heritable trait. Heritability was also supported by quantitative familial correlation of IFN-α activity, concordance in affected sib pairs and frequent transmission of the high IFN-α activity trait from parents to offspring. Autoantibodies to RNA-binding proteins and double-stranded DNA were associated with high IFN-α activity in SLE patients; however these autoantibodies were very uncommon in healthy family members and did not explain the observed familial correlations. The frequency of high IFN-α activity was similar across all studied ethnic backgrounds. These data suggest that high serum IFN-α activity is a complex heritable trait, which plays a primary role in SLE pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=34548438559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548438559&partnerID=8YFLogxK

U2 - 10.1038/sj.gene.6364408

DO - 10.1038/sj.gene.6364408

M3 - Article

C2 - 17581626

AN - SCOPUS:34548438559

VL - 8

SP - 492

EP - 502

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

IS - 6

ER -