High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system

Mohammad Eghtedari; Alexander Oraevsky; John A. Copland; Nicholas A. Kotov; Andre Conjusteau; Massoud Motamedi

doi:10.1021/nl070557d

High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system

Mohammad Eghtedari, Alexander Oraevsky, John A. Copland, Nicholas A. Kotov, Andre Conjusteau, Massoud Motamedi

Cancer Biology

Research output: Contribution to journal › Article › peer-review

331 Scopus citations

Abstract

The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 μL of gold nanorods solution at a concentration of 1.25 pM were injected into nude mice and detected using a single-channel acoustic transducer. LOIS was used to visualize the distribution of gold nanoparticles at a concentration of 125 pM in vivo when 100 μL of solution of gold nanoparticles was delivered subcutaneously. Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging.

Original language	English (US)
Pages (from-to)	1914-1918
Number of pages	5
Journal	Nano Letters
Volume	7
Issue number	7
DOIs	https://doi.org/10.1021/nl070557d
State	Published - Jul 2007

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl070557d

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title = "High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system",

abstract = "The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 μL of gold nanorods solution at a concentration of 1.25 pM were injected into nude mice and detected using a single-channel acoustic transducer. LOIS was used to visualize the distribution of gold nanoparticles at a concentration of 125 pM in vivo when 100 μL of solution of gold nanoparticles was delivered subcutaneously. Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging.",

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AU - Oraevsky, Alexander

AU - Copland, John A.

AU - Kotov, Nicholas A.

AU - Conjusteau, Andre

AU - Motamedi, Massoud

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AB - The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 μL of gold nanorods solution at a concentration of 1.25 pM were injected into nude mice and detected using a single-channel acoustic transducer. LOIS was used to visualize the distribution of gold nanoparticles at a concentration of 125 pM in vivo when 100 μL of solution of gold nanoparticles was delivered subcutaneously. Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging.

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High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system

Abstract

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