High-resolution chromoendoscopy for classifying colonic polyps: A multicenter study

Glenn M. Eisen, Christopher Y. Kim, David E. Fleischer, Richard A. Kozarek, David L. Carr-Locke, Theodore C M Li, Christopher J. Gostout, Stephen J. Heller, Elizabeth A. Montgomery, Firas H. Al-Kawas, James H. Lewis, Stanley B. Benjamin

Research output: Contribution to journalArticle

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Abstract

Background: Chromoendoscopy may reliably separate adenomatous from nonadenomatous polyps. The aim of this multicenter trial was to determine the accuracy of high-resolution chromoendoscopy for the determination of colonic polyp histology. Methods: This multicenter trial included 4 academic centers and a primary care practice. In 299 patients referred for routine colonoscopy or sigmoidoscopy, 520 polyps 10 mm in size were sprayed with indigo carmine dye. Using a high-resolution endoscope, the endoscopist predicted the histology of each polyp based on its surface characteristics. Hyperplastic polyps had a "pitted" surface pattern of orderly arranged "dots" that resembled surrounding normal mucosa. Adenomatous polyps had at least one surface "groove" or "sulcus." Each polyp was subsequently resected for histopathologic evaluation. Results: The resected polyps were comprised by 193 adenomas (37%), 225 hyperplastic polyps (43%), and 102 "other" types (20%). Forty polyps (7.7%) could not be classified by high resolution chromoendoscopy with indigo carmine dye. For the remaining polyps, the sensitivity, specificity, and negative predictive value of indigo carmine dye staining for adenomatous polyps were, respectively, 82%, 82%, and 88%. The results were consistent among the academic centers and the primary care practice. Conclusions: High-resolution chromoendoscopy with indigo carmine dye demonstrates morphologic detail of diminutive colorectal polyps that can reliably be used to separate adenomatous from nonadenomatous polyps.

Original languageEnglish (US)
Pages (from-to)687-694
Number of pages8
JournalGastrointestinal Endoscopy
Volume55
Issue number6
DOIs
StatePublished - May 2002

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Colonic Polyps
Polyps
Multicenter Studies
Indigo Carmine
Adenomatous Polyps
Coloring Agents
Primary Health Care
Histology
Sigmoidoscopy
Endoscopes
Colonoscopy
Adenoma
Mucous Membrane
Staining and Labeling
Sensitivity and Specificity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Eisen, G. M., Kim, C. Y., Fleischer, D. E., Kozarek, R. A., Carr-Locke, D. L., Li, T. C. M., ... Benjamin, S. B. (2002). High-resolution chromoendoscopy for classifying colonic polyps: A multicenter study. Gastrointestinal Endoscopy, 55(6), 687-694. https://doi.org/10.1067/mge.2002.123619

High-resolution chromoendoscopy for classifying colonic polyps : A multicenter study. / Eisen, Glenn M.; Kim, Christopher Y.; Fleischer, David E.; Kozarek, Richard A.; Carr-Locke, David L.; Li, Theodore C M; Gostout, Christopher J.; Heller, Stephen J.; Montgomery, Elizabeth A.; Al-Kawas, Firas H.; Lewis, James H.; Benjamin, Stanley B.

In: Gastrointestinal Endoscopy, Vol. 55, No. 6, 05.2002, p. 687-694.

Research output: Contribution to journalArticle

Eisen, GM, Kim, CY, Fleischer, DE, Kozarek, RA, Carr-Locke, DL, Li, TCM, Gostout, CJ, Heller, SJ, Montgomery, EA, Al-Kawas, FH, Lewis, JH & Benjamin, SB 2002, 'High-resolution chromoendoscopy for classifying colonic polyps: A multicenter study', Gastrointestinal Endoscopy, vol. 55, no. 6, pp. 687-694. https://doi.org/10.1067/mge.2002.123619
Eisen GM, Kim CY, Fleischer DE, Kozarek RA, Carr-Locke DL, Li TCM et al. High-resolution chromoendoscopy for classifying colonic polyps: A multicenter study. Gastrointestinal Endoscopy. 2002 May;55(6):687-694. https://doi.org/10.1067/mge.2002.123619
Eisen, Glenn M. ; Kim, Christopher Y. ; Fleischer, David E. ; Kozarek, Richard A. ; Carr-Locke, David L. ; Li, Theodore C M ; Gostout, Christopher J. ; Heller, Stephen J. ; Montgomery, Elizabeth A. ; Al-Kawas, Firas H. ; Lewis, James H. ; Benjamin, Stanley B. / High-resolution chromoendoscopy for classifying colonic polyps : A multicenter study. In: Gastrointestinal Endoscopy. 2002 ; Vol. 55, No. 6. pp. 687-694.
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AU - Gostout, Christopher J.

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