High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection

Paloma Anguita-Alonso, Arlen D. Hanssen, Douglas R. Osmon, Andrej Trampuz, James M. Steckelberg, Robin Patel

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Gentamicin and tobramycin are two aminoglycosides commonly impregnated into polymethylmethacrylate for treatment and prevention of prosthetic joint infection. Susceptibilities of staphylococci to aminoglycosides are not reported routinely in the United States. The gentamicin and tobramycin minimum inhibitory value of 93 staphylococci from patients with PJI were determined. Forty-one and 66% of the isolates were resistant to gentamicin and tobramycin, respectively. Methicillin-resistant Staphylococcus aureus isolates were more likely to be resistant to gentamicin or tobramycin than were their methicillin susceptible counterparts. The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalClinical Orthopaedics and Related Research
Issue number439
DOIs
StatePublished - Oct 2005

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Tobramycin
Aminoglycosides
Gentamicins
Staphylococcus
Joints
Polymethyl Methacrylate
Infection
Methicillin
Methicillin-Resistant Staphylococcus aureus
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection. / Anguita-Alonso, Paloma; Hanssen, Arlen D.; Osmon, Douglas R.; Trampuz, Andrej; Steckelberg, James M.; Patel, Robin.

In: Clinical Orthopaedics and Related Research, No. 439, 10.2005, p. 43-47.

Research output: Contribution to journalArticle

Anguita-Alonso, Paloma ; Hanssen, Arlen D. ; Osmon, Douglas R. ; Trampuz, Andrej ; Steckelberg, James M. ; Patel, Robin. / High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection. In: Clinical Orthopaedics and Related Research. 2005 ; No. 439. pp. 43-47.
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