TY - JOUR
T1 - High-quality nuclear genome for sarcoptes Scabiei—A critical resource for a neglected parasite
AU - Korhonen, Pasi K.
AU - Gasser, Robin B.
AU - Ma, Guangxu
AU - Wang, Tao
AU - Stroehlein, Andreas J.
AU - Young, Neil D.
AU - Ang, Ching Seng
AU - Fernando, Deepani D.
AU - Lu, Hieng C.
AU - Taylor, Sara
AU - Reynolds, Simone L.
AU - Mofiz, Ehtesham
AU - Najaraj, Shivashankar H.
AU - Gowda, Harsha
AU - Madugundu, Anil
AU - Renuse, Santosh
AU - Holt, Deborah
AU - Pandey, Akhilesh
AU - Papenfuss, Anthony T.
AU - Fischer, Katja
N1 - Publisher Copyright:
© 2020 Korhonen et al.
PY - 2020/10
Y1 - 2020/10
N2 - The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced ‘omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolo-mic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
AB - The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced ‘omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolo-mic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
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U2 - 10.1371/journal.pntd.0008720
DO - 10.1371/journal.pntd.0008720
M3 - Article
C2 - 33001992
AN - SCOPUS:85094933450
SN - 1935-2727
VL - 14
SP - 1
EP - 20
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
IS - 10
M1 - e0008720
ER -