High prevalence of celiac disease in Mexican Mestizo adults with type 1 diabetes mellitus

José María Remes-Troche, Aurelio Rios-Vaca, María Teresa Ramírez-Iglesias, Alberto Rubio-Tapia, Vicente Andrade-Zarate, Fanny Rodríguez-Vallejo, Francisco López-Maldonado, Francisco Javier Gomez-Perez, Luis F. Uscanga

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33 Scopus citations

Abstract

BACKGROUND AND AIMS: Recent studies have shown that celiac disease (CD) could affect 0.5% to 3% of the general population, including Mexican Mestizos, which represents a complex mixture of genetics, and constitutes the core of Mexican and Latin American populations. However, the association between CD and other conditions, specifically type-1 diabetes mellitus, in this population remains unknown. Thus, our aim was to determine the prevalence of both serologic and biopsy proven CD in Mexican Mestizo adults with type-1 diabetes. METHODS: Over a 6-month period, serum samples obtained from consecutive Mexican Mestizo adult patients (age ≥ 18 y) with type-1 diabetes were tested with a new generation human recombinant protein based IgA tissue transglutaminase enzyme-linked immunosorbent assay commercial kit. All patients with positive serologic test results underwent upper gastrointestinal endoscopy and small intestinal biopsies to confirm CD. RESULTS: Eighty-four type-1 diabetic patients were included (62 women, mean age 28.9±9 y). Overall, 9 patients (9/84) were positive for IgA tissue transglutaminase with a point prevalence of 10.7% (95% CI, 4%-17%). Seven patients agreed to undergo endoscopy. Five subjects had biopsy-proven CD (5.9%, 95% CI, 1.9%-13.3%). One patient had chronic diarrhea and other abdominal bloating; whereas the remaining 3 were asymptomatic. CD associated type-1 diabetic patients tended to have higher hemoglobin A1c levels (P=0.07), reflecting poor glycemic control. CONCLUSIONS: As in other populations, we demonstrated a high prevalence of biopsy-proven CD (5.9%) among Mexican Mestizo patients with type-1 diabetes. Clinicians should be aware of this common association in this ethnic group.

Original languageEnglish (US)
Pages (from-to)460-465
Number of pages6
JournalJournal of clinical gastroenterology
Volume42
Issue number5
DOIs
StatePublished - May 1 2008

Keywords

  • Celiac disease
  • Mexico
  • Prevalence
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Gastroenterology

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    Remes-Troche, J. M., Rios-Vaca, A., Ramírez-Iglesias, M. T., Rubio-Tapia, A., Andrade-Zarate, V., Rodríguez-Vallejo, F., López-Maldonado, F., Gomez-Perez, F. J., & Uscanga, L. F. (2008). High prevalence of celiac disease in Mexican Mestizo adults with type 1 diabetes mellitus. Journal of clinical gastroenterology, 42(5), 460-465. https://doi.org/10.1097/MCG.0b013e318046ea86