TY - JOUR
T1 - High normal fasting blood glucose is associated with dementia in Chinese elderly
AU - Mortimer, James A.
AU - Borenstein, Amy R.
AU - Ding, Ding
AU - Decarli, Charles
AU - Zhao, Qianhua
AU - Copenhaver, Cathleen
AU - Guo, Qihao
AU - Chu, Shugang
AU - Galasko, Douglas
AU - Salmon, David P.
AU - Dai, Qi
AU - Wu, Yougui
AU - Petersen, Ronald
AU - Hong, Zhen
N1 - Funding Information:
This study was supported by grant R21 AG028182 from the National Institute on Aging and Fogarty International Center , National Institutes of Health, Bethesda, MD. The authors thank the participants in the study for their many contributions.
PY - 2010/11
Y1 - 2010/11
N2 - Background: Diabetes is a risk factor for mild cognitive impairment (MCI) and dementia. However, the association between high normal fasting blood glucose (FBG) and dementia has not been studied. Methods: Polytomous logistic regression was used to assess the association of dementia and MCI with FBG in an age- and sex-matched sample of 32 dementia patients, 27 amnestic MCI (aMCI) patients, and 31 normal controls (NC). Analyses were repeated for those with normal FBG. Correlations between FBG and cognitive test scores were obtained. Results: Controlling for age, gender, education, body mass index, Hachinski Ischemic Score, magnetic resonance imaging (MRI) stroke, and normalized brain, hippocampal, and white matter hyperintensity MRI volumes; higher FBG was associated with dementia versus aMCI status (OR = 3.13; 95% CI, 1.28-7.69). This association remained (OR = 7.75; 95% CI, 1.10-55.56) when analyses were restricted to subjects with normal FBG. When dementia patients were compared with NC adjusting for age, gender, and education, a significant association with FBG also was seen (OR = 1.83; 95% CI, 1.09-3.08), but it was lost when vascular covariates were added to the model. FBG was not associated with aMCI status versus NC. Higher FBG was correlated with poorer performance on the Trailmaking Test Part B (P = .003). The percentage of dementia patients with high normal FBG (90%) was significantly higher than that of aMCI patients with high normal FBG (32.9%) (χ2 = 13.9, P < .001). Conclusions: Higher FBG was associated with dementia (vs. aMCI) independent of vascular risk factors and MRI indicators of vascular disease, and remained a significant risk factor when analyses were restricted to subjects with normal FBG. The results of this cross-sectional study suggest that a high normal level of FBG may be a risk factor for dementia.
AB - Background: Diabetes is a risk factor for mild cognitive impairment (MCI) and dementia. However, the association between high normal fasting blood glucose (FBG) and dementia has not been studied. Methods: Polytomous logistic regression was used to assess the association of dementia and MCI with FBG in an age- and sex-matched sample of 32 dementia patients, 27 amnestic MCI (aMCI) patients, and 31 normal controls (NC). Analyses were repeated for those with normal FBG. Correlations between FBG and cognitive test scores were obtained. Results: Controlling for age, gender, education, body mass index, Hachinski Ischemic Score, magnetic resonance imaging (MRI) stroke, and normalized brain, hippocampal, and white matter hyperintensity MRI volumes; higher FBG was associated with dementia versus aMCI status (OR = 3.13; 95% CI, 1.28-7.69). This association remained (OR = 7.75; 95% CI, 1.10-55.56) when analyses were restricted to subjects with normal FBG. When dementia patients were compared with NC adjusting for age, gender, and education, a significant association with FBG also was seen (OR = 1.83; 95% CI, 1.09-3.08), but it was lost when vascular covariates were added to the model. FBG was not associated with aMCI status versus NC. Higher FBG was correlated with poorer performance on the Trailmaking Test Part B (P = .003). The percentage of dementia patients with high normal FBG (90%) was significantly higher than that of aMCI patients with high normal FBG (32.9%) (χ2 = 13.9, P < .001). Conclusions: Higher FBG was associated with dementia (vs. aMCI) independent of vascular risk factors and MRI indicators of vascular disease, and remained a significant risk factor when analyses were restricted to subjects with normal FBG. The results of this cross-sectional study suggest that a high normal level of FBG may be a risk factor for dementia.
KW - Alzheimer's disease
KW - Cognitive performance
KW - Dementia
KW - Diabetes
KW - Fasting blood glucose
KW - Hippocampal volume
KW - Magnetic resonance imaging
KW - Mild cognitive impairment
KW - Vascular risk
KW - White matter hyperintensity
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U2 - 10.1016/j.jalz.2010.03.017
DO - 10.1016/j.jalz.2010.03.017
M3 - Article
C2 - 21044774
AN - SCOPUS:78049490388
SN - 1552-5260
VL - 6
SP - 440
EP - 447
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 6
ER -