High mobility group AT-hook 2 is overexpressed in hepatoblastoma

Chung Ta Lee, Lizhi Zhang, Taofic Mounajjed, Tsung Teh Wu

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Hepatoblastoma is the most frequent malignant hepatic tumor in children. Expression of high mobility group AT-hook 2, an architectural nuclear factor and marker for hepatic progenitor cells, has not been studied in detail in hepatocellular neoplasms. Immunohistochemical stains using antibodies against high mobility group AT-hook 2, β-catenin, glypican-3, p53, and Ki-67 were performed in 15 hepatoblastomas, 15 fibrolamellar hepatocellular carcinomas, 34 hepatocellular carcinomas (12, ≤30 years old; 22, >30 years old), and 22 hepatic adenomas. High mobility group AT-hook 2 was expressed in all 15 hepatoblastomas, including all fetal and embryonal components, significantly higher than in 41.7% (5/12) of hepatocellular carcinomas of 30 years or younger (P =.001) and in 9% (2/22) of hepatocellular carcinomas of older than 30 years (P<.001). Aberrant β-catenin expression was detected in 80% (12/15) of hepatoblastomas, 41.6% (5/12) of hepatocellular carcinomas of 30 years or younger, and 18.2% (4/22) of hepatocellular carcinomas of older than 30 years. All 15 fibrolamellar hepatocellular carcinomas and 22 hepatic adenomas were negative for high mobility group AT-hook 2 or β-catenin. High mobility group AT-hook 2 and β-catenin expression correlated positively (P =.017; τ = 0.522) in 34 hepatocellular carcinomas. β-Catenin and glypican-3 exhibited a distinct spatial distribution within hepatoblastomas; glypican-3 was more frequently expressed in fetal components (P =.007), whereas β-catenin tended to be more frequently expressed in embryonal components (P =.062). In conclusion, high mobility group AT-hook 2 is expressed in all hepatoblastomas and could be used as a sensitive marker in their diagnosis. High mobility group AT-hook 2 was also expressed in a subset of hepatocellular carcinomas in association with β-catenin expression; this might represent a subtype of hepatocellular carcinoma with hepatic progenitor cell differentiation.

Original languageEnglish (US)
Pages (from-to)802-810
Number of pages9
JournalHuman Pathology
Volume44
Issue number5
DOIs
StatePublished - May 1 2013

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Keywords

  • Glypican-3
  • HMGA2
  • Hepatoblastoma
  • Hepatocellular carcinoma
  • Immunohistochemistry
  • β-catenin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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