HIGH LEVELS OF CYTOMEGALOVIRUS ANTIBODY IN PATIENTS REQUIRING VASCULAR SURGERY FOR ATHEROSCLEROSIS

E. Adam, J. L. Probtsfield, J. Burek, C. H. Mccollum, J. L. Melnick, B. L. Petrie, K. R. Bailey, M. E. Debakey

Research output: Contribution to journalArticle

249 Scopus citations

Abstract

157 caucasian male patients undergoing vascular surgery for atherosclerosis and a matched control group of patients with high cholesterol levels were screened for antibodies to cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV1) and type 2 (HSV2), indicative of persistent infection. The prevalence of CMV antibodies was higher in the surgical group than in the control group (90% and 74%, respectively), and a significantly greater percentage (p<0.001) of surgical cases than controls had high titres of CMV antibodies (57% and 26%, respectively). Small but not significant differences in antibodies to HSV1 were observed, and there were no differences in HSV2 antibody titres. For each virus there was no correlation between antibody titre and blood levels of total cholesterol or triglycerides. It is suggested that periodically activated virus may have a role in the pathogenesis of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)291-293
Number of pages3
JournalThe Lancet
Volume330
Issue number8554
DOIs
StatePublished - Aug 8 1987

ASJC Scopus subject areas

  • Medicine(all)

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    Adam, E., Probtsfield, J. L., Burek, J., Mccollum, C. H., Melnick, J. L., Petrie, B. L., Bailey, K. R., & Debakey, M. E. (1987). HIGH LEVELS OF CYTOMEGALOVIRUS ANTIBODY IN PATIENTS REQUIRING VASCULAR SURGERY FOR ATHEROSCLEROSIS. The Lancet, 330(8554), 291-293. https://doi.org/10.1016/S0140-6736(87)90888-9