High-intensity interval training improves metabolic syndrome and body composition in outpatient cardiac rehabilitation patients with myocardial infarction

Yaoshan Dun, Randal J. Thomas, Joshua R. Smith, Jose R. Medina-Inojosa, Ray W. Squires, Amanda R. Bonikowske, Hsuhang Huang, Suixin Liu, Thomas P Olson

Research output: Contribution to journalArticle

Abstract

Background: To examine the effect of high-intensity interval training (HIIT) on metabolic syndrome (MetS) and body composition in cardiac rehabilitation (CR) patients with myocardial infarction (MI). Methods: We retrospectively screened 174 consecutive patients with MetS enrolled in CR following MI between 2015 and 2018. We included 56 patients who completed 36 CR sessions and pre-post dual-energy X-ray absorptiometry. Of these patients, 42 engaged in HIIT and 14 in moderate-intensity continuous training (MICT). HIIT included 4-8 intervals of high-intensity (30-60 s at RPE 15-17 [Borg 6-20]) and low-intensity (1-5 min at RPE < 14), and MICT included 20-45 min of exercise at RPE 12-14. MetS and body composition variables were compared between MICT and HIIT groups. Results: Compared to MICT, HIIT demonstrated greater reductions in MetS (relative risk = 0.5, 95% CI 0.33-0.75, P <.001), MetS z-score (- 3.6 ± 2.9 vs. - 0.8 ± 3.8, P <.001) and improved MetS components: waist circumference (- 3 ± 5 vs. 1 ± 5 cm, P =.01), fasting blood glucose (- 25.8 ± 34.8 vs. - 3.9 ± 25.8 mg/dl, P <.001), triglycerides (- 67.8 ± 86.7 vs. - 10.4 ± 105.3 mg/dl, P <.001), and diastolic blood pressure (- 7 ± 11 vs. 0 ± 13 mmHg, P =.001). HIIT group demonstrated greater reductions in body fat mass (- 2.1 ± 2.1 vs. 0 ± 2.2 kg, P =.002), with increased body lean mass (0.9 ± 1.9 vs. - 0.9 ± 3.2 kg, P =.01) than the MICT. After matching for exercise energy expenditure, HIIT-induced improvements persisted for MetS z-score (P <.001), MetS components (P <.05), body fat mass (P =.002), body fat (P =.01), and lean mass (P =.03). Conclusions: Our data suggest that, compared to MICT, supervised HIIT results in greater improvements in MetS and body composition in MI patients with MetS undergoing CR.

Original languageEnglish (US)
Article number104
JournalCardiovascular Diabetology
Volume18
Issue number1
DOIs
StatePublished - Aug 14 2019

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Body Composition
Outpatients
Myocardial Infarction
Adipose Tissue
Cardiac Rehabilitation
High-Intensity Interval Training
Exercise
Blood Pressure
Photon Absorptiometry
Waist Circumference
Energy Metabolism
Blood Glucose
Fasting
Triglycerides

Keywords

  • Body composition
  • Cardiac rehabilitation
  • High-intensity interval training
  • Metabolic syndrome
  • Myocardial infarction

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

High-intensity interval training improves metabolic syndrome and body composition in outpatient cardiac rehabilitation patients with myocardial infarction. / Dun, Yaoshan; Thomas, Randal J.; Smith, Joshua R.; Medina-Inojosa, Jose R.; Squires, Ray W.; Bonikowske, Amanda R.; Huang, Hsuhang; Liu, Suixin; Olson, Thomas P.

In: Cardiovascular Diabetology, Vol. 18, No. 1, 104, 14.08.2019.

Research output: Contribution to journalArticle

Dun, Yaoshan ; Thomas, Randal J. ; Smith, Joshua R. ; Medina-Inojosa, Jose R. ; Squires, Ray W. ; Bonikowske, Amanda R. ; Huang, Hsuhang ; Liu, Suixin ; Olson, Thomas P. / High-intensity interval training improves metabolic syndrome and body composition in outpatient cardiac rehabilitation patients with myocardial infarction. In: Cardiovascular Diabetology. 2019 ; Vol. 18, No. 1.
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AU - Thomas, Randal J.

AU - Smith, Joshua R.

AU - Medina-Inojosa, Jose R.

AU - Squires, Ray W.

AU - Bonikowske, Amanda R.

AU - Huang, Hsuhang

AU - Liu, Suixin

AU - Olson, Thomas P

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N2 - Background: To examine the effect of high-intensity interval training (HIIT) on metabolic syndrome (MetS) and body composition in cardiac rehabilitation (CR) patients with myocardial infarction (MI). Methods: We retrospectively screened 174 consecutive patients with MetS enrolled in CR following MI between 2015 and 2018. We included 56 patients who completed 36 CR sessions and pre-post dual-energy X-ray absorptiometry. Of these patients, 42 engaged in HIIT and 14 in moderate-intensity continuous training (MICT). HIIT included 4-8 intervals of high-intensity (30-60 s at RPE 15-17 [Borg 6-20]) and low-intensity (1-5 min at RPE < 14), and MICT included 20-45 min of exercise at RPE 12-14. MetS and body composition variables were compared between MICT and HIIT groups. Results: Compared to MICT, HIIT demonstrated greater reductions in MetS (relative risk = 0.5, 95% CI 0.33-0.75, P <.001), MetS z-score (- 3.6 ± 2.9 vs. - 0.8 ± 3.8, P <.001) and improved MetS components: waist circumference (- 3 ± 5 vs. 1 ± 5 cm, P =.01), fasting blood glucose (- 25.8 ± 34.8 vs. - 3.9 ± 25.8 mg/dl, P <.001), triglycerides (- 67.8 ± 86.7 vs. - 10.4 ± 105.3 mg/dl, P <.001), and diastolic blood pressure (- 7 ± 11 vs. 0 ± 13 mmHg, P =.001). HIIT group demonstrated greater reductions in body fat mass (- 2.1 ± 2.1 vs. 0 ± 2.2 kg, P =.002), with increased body lean mass (0.9 ± 1.9 vs. - 0.9 ± 3.2 kg, P =.01) than the MICT. After matching for exercise energy expenditure, HIIT-induced improvements persisted for MetS z-score (P <.001), MetS components (P <.05), body fat mass (P =.002), body fat (P =.01), and lean mass (P =.03). Conclusions: Our data suggest that, compared to MICT, supervised HIIT results in greater improvements in MetS and body composition in MI patients with MetS undergoing CR.

AB - Background: To examine the effect of high-intensity interval training (HIIT) on metabolic syndrome (MetS) and body composition in cardiac rehabilitation (CR) patients with myocardial infarction (MI). Methods: We retrospectively screened 174 consecutive patients with MetS enrolled in CR following MI between 2015 and 2018. We included 56 patients who completed 36 CR sessions and pre-post dual-energy X-ray absorptiometry. Of these patients, 42 engaged in HIIT and 14 in moderate-intensity continuous training (MICT). HIIT included 4-8 intervals of high-intensity (30-60 s at RPE 15-17 [Borg 6-20]) and low-intensity (1-5 min at RPE < 14), and MICT included 20-45 min of exercise at RPE 12-14. MetS and body composition variables were compared between MICT and HIIT groups. Results: Compared to MICT, HIIT demonstrated greater reductions in MetS (relative risk = 0.5, 95% CI 0.33-0.75, P <.001), MetS z-score (- 3.6 ± 2.9 vs. - 0.8 ± 3.8, P <.001) and improved MetS components: waist circumference (- 3 ± 5 vs. 1 ± 5 cm, P =.01), fasting blood glucose (- 25.8 ± 34.8 vs. - 3.9 ± 25.8 mg/dl, P <.001), triglycerides (- 67.8 ± 86.7 vs. - 10.4 ± 105.3 mg/dl, P <.001), and diastolic blood pressure (- 7 ± 11 vs. 0 ± 13 mmHg, P =.001). HIIT group demonstrated greater reductions in body fat mass (- 2.1 ± 2.1 vs. 0 ± 2.2 kg, P =.002), with increased body lean mass (0.9 ± 1.9 vs. - 0.9 ± 3.2 kg, P =.01) than the MICT. After matching for exercise energy expenditure, HIIT-induced improvements persisted for MetS z-score (P <.001), MetS components (P <.05), body fat mass (P =.002), body fat (P =.01), and lean mass (P =.03). Conclusions: Our data suggest that, compared to MICT, supervised HIIT results in greater improvements in MetS and body composition in MI patients with MetS undergoing CR.

KW - Body composition

KW - Cardiac rehabilitation

KW - High-intensity interval training

KW - Metabolic syndrome

KW - Myocardial infarction

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