Abstract
In approximately 5% to 10% of gastric mucosa - associated lymphoid tissue (MALT) lymphomas, evidence of Helicobacter pylori infection is absent, and their pathogenesis is poorly understood. We reviewed the clinical data and histology, and we examined t(11;18)(q21;q21) and BCL10 expression pattern in 17 such cases. In each case, the absence of H pylori was confirmed by negative serology and histology/immunohistochemistry. Five cases with stage IE disease were first treated with antibiotics, and none of them showed any endoscopic or histologic response. Review of the histology failed to identify any apparent difference between gastric MALT lymphomas with and without H pylori infection. Reverse transcription-polymerase chain reaction (RT-PCR) showed t(11;18)(q21;q21) in 9 (53%) of 17 cases, more frequent in lymphomas at stage IIE or above (5 of 6) than those at stage IE (3 of 10). Two t(11;18)(q21;q21)-positive lymphomas were treated by partial gastrectomy and more than 16 years later showed lymphoma relapse in the gastric stump with dissemination to other mucosal sites, poorly responsive to therapy. BCL10 nuclear expression was observed in 7 of 8 t(11;18)(q21; q21)-positive cases and 4 of 7 t(11;18)(q21; q21)-negative cases, including one case suspicious for a BCL10-involved chromosomal translocation. Our results show that t(11;18)(q21;q21) occurs at a high frequency in H pylori-negative gastric MALT lymphomas. Translocation-positive gastric MALT lymphomas tend to be aggressive, and patients with such lymphomas might benefit from prompt treatment and close follow-up.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2547-2550 |
| Number of pages | 4 |
| Journal | Blood |
| Volume | 101 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Hematology
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High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphoma. / Ye, Hongtao; Liu, Hongxiang; Raderer, Markus; Chott, Andreas; Ruskone-Fourmestraux, Agnes; Wotherspoon, Andrew; Dyer, Martin J S; Chuang, Shih Sung; Dogan, Ahmet; Isaacson, Peter G.; Du, Ming Qing.
In: Blood, Vol. 101, No. 7, 01.04.2003, p. 2547-2550.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphoma
AU - Ye, Hongtao
AU - Liu, Hongxiang
AU - Raderer, Markus
AU - Chott, Andreas
AU - Ruskone-Fourmestraux, Agnes
AU - Wotherspoon, Andrew
AU - Dyer, Martin J S
AU - Chuang, Shih Sung
AU - Dogan, Ahmet
AU - Isaacson, Peter G.
AU - Du, Ming Qing
PY - 2003/4/1
Y1 - 2003/4/1
N2 - In approximately 5% to 10% of gastric mucosa - associated lymphoid tissue (MALT) lymphomas, evidence of Helicobacter pylori infection is absent, and their pathogenesis is poorly understood. We reviewed the clinical data and histology, and we examined t(11;18)(q21;q21) and BCL10 expression pattern in 17 such cases. In each case, the absence of H pylori was confirmed by negative serology and histology/immunohistochemistry. Five cases with stage IE disease were first treated with antibiotics, and none of them showed any endoscopic or histologic response. Review of the histology failed to identify any apparent difference between gastric MALT lymphomas with and without H pylori infection. Reverse transcription-polymerase chain reaction (RT-PCR) showed t(11;18)(q21;q21) in 9 (53%) of 17 cases, more frequent in lymphomas at stage IIE or above (5 of 6) than those at stage IE (3 of 10). Two t(11;18)(q21;q21)-positive lymphomas were treated by partial gastrectomy and more than 16 years later showed lymphoma relapse in the gastric stump with dissemination to other mucosal sites, poorly responsive to therapy. BCL10 nuclear expression was observed in 7 of 8 t(11;18)(q21; q21)-positive cases and 4 of 7 t(11;18)(q21; q21)-negative cases, including one case suspicious for a BCL10-involved chromosomal translocation. Our results show that t(11;18)(q21;q21) occurs at a high frequency in H pylori-negative gastric MALT lymphomas. Translocation-positive gastric MALT lymphomas tend to be aggressive, and patients with such lymphomas might benefit from prompt treatment and close follow-up.
AB - In approximately 5% to 10% of gastric mucosa - associated lymphoid tissue (MALT) lymphomas, evidence of Helicobacter pylori infection is absent, and their pathogenesis is poorly understood. We reviewed the clinical data and histology, and we examined t(11;18)(q21;q21) and BCL10 expression pattern in 17 such cases. In each case, the absence of H pylori was confirmed by negative serology and histology/immunohistochemistry. Five cases with stage IE disease were first treated with antibiotics, and none of them showed any endoscopic or histologic response. Review of the histology failed to identify any apparent difference between gastric MALT lymphomas with and without H pylori infection. Reverse transcription-polymerase chain reaction (RT-PCR) showed t(11;18)(q21;q21) in 9 (53%) of 17 cases, more frequent in lymphomas at stage IIE or above (5 of 6) than those at stage IE (3 of 10). Two t(11;18)(q21;q21)-positive lymphomas were treated by partial gastrectomy and more than 16 years later showed lymphoma relapse in the gastric stump with dissemination to other mucosal sites, poorly responsive to therapy. BCL10 nuclear expression was observed in 7 of 8 t(11;18)(q21; q21)-positive cases and 4 of 7 t(11;18)(q21; q21)-negative cases, including one case suspicious for a BCL10-involved chromosomal translocation. Our results show that t(11;18)(q21;q21) occurs at a high frequency in H pylori-negative gastric MALT lymphomas. Translocation-positive gastric MALT lymphomas tend to be aggressive, and patients with such lymphomas might benefit from prompt treatment and close follow-up.
UR - http://www.scopus.com/inward/record.url?scp=0037769787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037769787&partnerID=8YFLogxK
U2 - 10.1182/blood-2002-10-3167
DO - 10.1182/blood-2002-10-3167
M3 - Article
C2 - 12517817
AN - SCOPUS:0037769787
VL - 101
SP - 2547
EP - 2550
JO - Blood
JF - Blood
SN - 0006-4971
IS - 7
ER -