High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): Cytogenetic features, clinical characteristics and outcome

L. Chilton, G. Buck, C. J. Harrison, R. P. Ketterling, J. M. Rowe, M. S. Tallman, A. H. Goldstone, A. K. Fielding, A. V. Moorman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

High hyperdiploidy (HeH, 51-65 chromosomes) is an established genetic subtype of acute lymphoblastic leukaemia (ALL). The clinical and cytogenetic features as well as outcome of HeH among adolescents and adults have not been thoroughly investigated. Among 1232 B-cell precursor ALL patients (15-65 years) treated in the UKALLXII/ECOG2993 trial, 160 (13%) had a HeH karyotype, including 80 patients aged >24 years. The frequency of HeH was the same in Philadelphia chromosome (Ph)-positive and-negative cases, but Ph-positive patients were older. The cytogenetic profiles of Ph-positive and Ph-negative HeH cases were similar, although trisomy 2 was strongly associated with Ph-positive HeH. Overall, Ph-positive HeH patients did not have an inferior overall survival compared with Ph-negative patients (P=0.2: 50 vs 57% at 5 years). Trisomy of chromosome 4 was associated with a superior outcome in Ph-negative patients, whereas +5 and +20 were associated with an inferior outcome in Ph-positive and Ph-negative patients, respectively. All three markers retained significance in multivariate analysis adjusting for age and white cell count: hazard ratio for risk of death 0.47 (95% CI: 0.27-0.84) (P=0.01), 3.73 (1.51-9.21) (P=0.004) and 2.63 (1.25-5.54) (P=0.01), respectively. In conclusion, HeH is an important subtype of ALL at all ages and displays outcome heterogeneity according to chromosomal gain.

Original languageEnglish (US)
Pages (from-to)1511-1518
Number of pages8
JournalLeukemia
Volume28
Issue number7
DOIs
StatePublished - Jul 2014

    Fingerprint

Keywords

  • acute lymphoblastic leukaemia
  • adolescents
  • adults
  • chromosomal abnormalities
  • high hyperdiploidy
  • prognosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Chilton, L., Buck, G., Harrison, C. J., Ketterling, R. P., Rowe, J. M., Tallman, M. S., Goldstone, A. H., Fielding, A. K., & Moorman, A. V. (2014). High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): Cytogenetic features, clinical characteristics and outcome. Leukemia, 28(7), 1511-1518. https://doi.org/10.1038/leu.2013.379