High high-density lipoprotein-cholesterol reduces risk and extent of percutaneous coronary intervention-related myocardial infarction and improves long-term outcome in patients undergoing elective percutaneous coronary intervention

Katherine J.E. Sattler, Jörg Herrmann, Ehriban Yün, Nils Lehmann, Zhen Wang, Gerd Heusch, Stefan Sack, Raimund Erbel, Bodo Levkau

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

AimsThe study tested whether high-density lipoprotein-cholesterol (HDL-C) has an effect on percutaneous coronary intervention (PCI)-induced myocardial infarction and its prognosis. Elevation of cardiac troponin I (cTnI) > 3× upper normal limit after PCI is defined as PCI-related myocardial infarction (PMI) and is associated with a negative prognosis. No data exist on the relationship of HDL-C to PMI and PMI-related outcome.Methods and resultsPre-procedural HDL-C levels and post-procedural peak cTnI levels were collected in 350 patients undergoing PCI. Data were analysed for PMI and for acute myocardial infarction (AMI) during follow-up. Patients with PMI (n = 115) had lower HDL-C levels than patients without PMI [n = 235; 1.17 mmol/L (0.75-2.51) vs. 1.27 mmol/L (0.70-2.87), P < 0.001]. Pre-procedural HDL-C levels were inversely related to the occurrence of PMI [odds ratio for PMI: 0.884, 95 CI: 0.80, 0.98; P = 0.02 for an HDL-C-increment of 5 mg/dL (0.13 mmol/L)] and to AMI during follow-up [hazard ratio (HR): 0.697, 95 CI: 0.54, 0.90; P = 0.005]. The occurrence of PMI was associated with an elevated HR for AMI (4.702, 95 CI: 1.79, 12.37; P = 0.002). Low-risk levels of pre-procedural HDL-C [men ≥40 mg/dL (≥1.03 mmol/L), women ≥45 mg/dL (≥1.16 mmol/L)] did not influence the negative effects of PMI on outcome (HR: 5.510, 95 CI: 1.43, 21.31; P = 0.013) and reduction of AMI-free survival [mean AMI-free survival time with PMI: 1167.5 days (95 CI: 1098.27, 1236.67) vs. 1240.7 days (95 CI: 1220.94, 1290.49) without PMI; log-rank P = 0.005].

Original languageEnglish (US)
Pages (from-to)1894-1902
Number of pages9
JournalEuropean heart journal
Volume30
Issue number15
DOIs
StatePublished - Aug 1 2009

Keywords

  • Coronary artery disease
  • High-density lipoprotein-cholesterol
  • PCI-related myocardial infarction
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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