Abstract
Adamantinoma of the long bones is a rare, typically low-grade malignant tumor that frequently involves the tibia. Radiographically, adamantinoma is characteristically a lytic, intracortical, and expansile lesion with variable margins. Histologically, adamantinoma is a bimorphic neoplasm, composed of epithelial and osteofibrous elements. Herein, we describe a 72-year-old man with a long-standing tibial mass that, on imaging, rapidly developed cortical destruction with soft tissue extension. Imaging revealed no evidence of a distant site of origin. Needle core biopsy demonstrated high-grade squamous cell carcinoma, and metastasis was initially favored. However, the combined clinicoradiologic and pathologic features were most compatible with a high-grade squamous cell carcinoma arising in adamantinoma. The diagnosis was confirmed in the resection specimen. Both the age at presentation and histologic features make this case unusual and highlight a potential for misdiagnosis in the evaluation of squamous cell carcinoma–containing lesions of the tibia, reinforcing the importance of clinicoradiologic correlation in bone pathology.
Original language | English (US) |
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Pages (from-to) | 123-128 |
Number of pages | 6 |
Journal | Human Pathology |
Volume | 91 |
DOIs | |
State | Published - Sep 2019 |
Keywords
- Adamantinoma of the long bone
- High-grade
- Metastasis
- Squamous cell carcinoma
- Tibia
ASJC Scopus subject areas
- Pathology and Forensic Medicine