High grade leiomyosarcoma mimicking a recurrent angiomyxoma in the perineum

Neha Sood, Abhisek Swaika, Bashar Hanooshi, James Waldorf, Jennifer Peterson, Kevin Wu, Steven Attia, Tri A. Dinh

Research output: Contribution to journalArticle

Abstract

Perineal leiomyosarcoma is an extremely rare and aggressive cancer with a high metastatic potential and no defined standard treatment. There are only a few (six) reported cases in the literature. We report the case of a 67-year-old woman with a perineal leiomyosarcoma arising at the same site of a previously resected superficial angiomyxoma. Initially, she was treated for a presumptive recurrence of angiomyxoma. As she did not respond to medical therapy, she underwent repeat surgical excision. Pathology revealed a high grade leiomyosarcoma, histologically strikingly distinct from the initial diagnosis. She received adjuvant local radiation therapy, and remains without evidence of recurrent disease 36 months after completion of all therapy. This is the first reported case of a high grade perineal leiomyosarcoma originating at the same site as a resected benign superficial angiomyxoma. Our case emphasizes the necessity of a prompt histological diagnosis in cases of presumed recurrent perineal angiomyxoma.

Original languageEnglish (US)
Article number5875
Pages (from-to)66-68
Number of pages3
JournalRare Tumors
Volume7
Issue number2
DOIs
StatePublished - 2015

Fingerprint

Perineum
Myxoma
Leiomyosarcoma
Radiotherapy
Therapeutics
Pathology
Recurrence
Neoplasms

Keywords

  • Angiomyxoma
  • Leiomyosarcoma
  • Perineum

ASJC Scopus subject areas

  • Oncology
  • Histology

Cite this

Sood, N., Swaika, A., Hanooshi, B., Waldorf, J., Peterson, J., Wu, K., ... Dinh, T. A. (2015). High grade leiomyosarcoma mimicking a recurrent angiomyxoma in the perineum. Rare Tumors, 7(2), 66-68. [5875]. https://doi.org/10.4081/rt.2015.5875

High grade leiomyosarcoma mimicking a recurrent angiomyxoma in the perineum. / Sood, Neha; Swaika, Abhisek; Hanooshi, Bashar; Waldorf, James; Peterson, Jennifer; Wu, Kevin; Attia, Steven; Dinh, Tri A.

In: Rare Tumors, Vol. 7, No. 2, 5875, 2015, p. 66-68.

Research output: Contribution to journalArticle

Sood, N, Swaika, A, Hanooshi, B, Waldorf, J, Peterson, J, Wu, K, Attia, S & Dinh, TA 2015, 'High grade leiomyosarcoma mimicking a recurrent angiomyxoma in the perineum', Rare Tumors, vol. 7, no. 2, 5875, pp. 66-68. https://doi.org/10.4081/rt.2015.5875
Sood N, Swaika A, Hanooshi B, Waldorf J, Peterson J, Wu K et al. High grade leiomyosarcoma mimicking a recurrent angiomyxoma in the perineum. Rare Tumors. 2015;7(2):66-68. 5875. https://doi.org/10.4081/rt.2015.5875
Sood, Neha ; Swaika, Abhisek ; Hanooshi, Bashar ; Waldorf, James ; Peterson, Jennifer ; Wu, Kevin ; Attia, Steven ; Dinh, Tri A. / High grade leiomyosarcoma mimicking a recurrent angiomyxoma in the perineum. In: Rare Tumors. 2015 ; Vol. 7, No. 2. pp. 66-68.
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