Displasia de alto grado como factor de riesgo de neoplasia colorrectal avanzada metacrónica, en pacientes con adenomas avanzados

Translated title of the contribution: High-grade dysplasia as a risk factor of metachronic advanced neoplasms in patients with advanced adenomas

Antonio Z. Gimeno-García, Francisco Ramírez, Victòria Gonzalo, Francesc Balaguer, Anna Petit, Maria Pellisé, Josep Llach, Josep M. Bordas, Josep M. Piqué, Antoni Castells

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

BACKGROUND: Patients with advanced adenomas (AA) have a high risk of developing advanced colorectal neoplasms. Therefore, shorter monitoring intervals have been recommended in this patient subgroup. High grade dysplasia (HGD) is the main marker of cancer transformation. However, its predictive value for developing advanced neoplams in patients with advanced adenoma is unknown. AIM: To investigate if HGD increases the risk for developing advanced neoplasms in patients with AA. METHODS: Between January 1996 and December 1997 every patient with an AA endoscopically resected were considered for inclusion. Patients with a history of colorectal cancer (CRC), inflammatory bowel disease, familial adenomatous polyposis or patients who met the Amsterdam criteria, and those without colonoscopic monitoring were excluded. We assessed the development of advanced neoplasms during the study period. RESULTS: 71 patients were included and classified into 2 groups, depending on the presence (n = 49) or lack (n = 22) of HGD in the initial colonoscopy. The probability of developing advanced neoplasms (log rank, p = 0.47; Breslow, p = 0.58) or AA with HGD (log rank, p = 0.47; Breslow, p = 0.53) in the study period was similar between both groups. The number of metachronic polyps (p = 0.67), adenomas (p = 0.73), AA (p = 0.93) and AA with HGD (p = 0.88) was also similar. CONCLUSION: The risk of developing advanced neoplasms is not different between AA with HGD and those with other characteristics of AA (villous pattern and larger than 1 cm). Therefore, changes in monitoring intervals are not warranted.

Translated title of the contributionHigh-grade dysplasia as a risk factor of metachronic advanced neoplasms in patients with advanced adenomas
Original languageSpanish
Pages (from-to)207-211
Number of pages5
JournalGastroenterologia y Hepatologia
Volume30
Issue number4
DOIs
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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