High-frequency oscillations in awake patients undergoing brain tumor-related epilepsy surgery

Anteneh Feyissa, Gregory Alan Worrell, William O. Tatum, Deependra Mahato, Benjamin Brinkmann, Steven Rosenfeld, Karim Refaey, Perry S. Bechtle, Alfredo Quinones-Hinojosa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective To examine the relationship between high-frequency oscillations (HFOs) and the presence of preoperative seizures, World Health Organization tumor grade, and isocitrate dehydrogenase 1 (IDH1) mutational status in gliomas. Methods We retrospectively studied intraoperative electrocorticography recorded in 16 patients with brain tumor (12 presenting with seizures) who underwent awake craniotomy and surgical resection between September 2016 and June 2017. The number and distribution of HFOs were determined and quantified visually and with an automated HFO detector. Results Five patients had low-grade (1 with grade I and 4 with grade II) and 11 had high-grade (6 with grade III and 5 with grade IV) brain tumors. An IDH1 mutation was found in 6 patients. Patients with a history of preoperative seizures were more likely to have HFOs than those without preoperative seizures (9 of 12 vs 0 of 4, p = 0.02). The rate of HFOs was higher in patients with IDH1 mutant (mean 7.2 per minute) than IDH wild-type (mean 2.3 per minute) genotype (p = 0.03). Conclusions HFOs are common in brain tumor-related epilepsy, and HFO rate may be a useful measure of epileptogenicity in gliomas. Our findings further support the notion that IDH1 mutant genotype is more epileptogenic than IDH1 wild-type genotype gliomas.

Original languageEnglish (US)
Pages (from-to)e1119-e1125
JournalNeurology
Volume90
Issue number13
DOIs
StatePublished - Mar 27 2018

Fingerprint

Isocitrate Dehydrogenase
Brain Neoplasms
Epilepsy
Seizures
Glioma
Genotype
Craniotomy
Mutation
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

High-frequency oscillations in awake patients undergoing brain tumor-related epilepsy surgery. / Feyissa, Anteneh; Worrell, Gregory Alan; Tatum, William O.; Mahato, Deependra; Brinkmann, Benjamin; Rosenfeld, Steven; Refaey, Karim; Bechtle, Perry S.; Quinones-Hinojosa, Alfredo.

In: Neurology, Vol. 90, No. 13, 27.03.2018, p. e1119-e1125.

Research output: Contribution to journalArticle

@article{508d7b5eea1249d3977468236d26a75e,
title = "High-frequency oscillations in awake patients undergoing brain tumor-related epilepsy surgery",
abstract = "Objective To examine the relationship between high-frequency oscillations (HFOs) and the presence of preoperative seizures, World Health Organization tumor grade, and isocitrate dehydrogenase 1 (IDH1) mutational status in gliomas. Methods We retrospectively studied intraoperative electrocorticography recorded in 16 patients with brain tumor (12 presenting with seizures) who underwent awake craniotomy and surgical resection between September 2016 and June 2017. The number and distribution of HFOs were determined and quantified visually and with an automated HFO detector. Results Five patients had low-grade (1 with grade I and 4 with grade II) and 11 had high-grade (6 with grade III and 5 with grade IV) brain tumors. An IDH1 mutation was found in 6 patients. Patients with a history of preoperative seizures were more likely to have HFOs than those without preoperative seizures (9 of 12 vs 0 of 4, p = 0.02). The rate of HFOs was higher in patients with IDH1 mutant (mean 7.2 per minute) than IDH wild-type (mean 2.3 per minute) genotype (p = 0.03). Conclusions HFOs are common in brain tumor-related epilepsy, and HFO rate may be a useful measure of epileptogenicity in gliomas. Our findings further support the notion that IDH1 mutant genotype is more epileptogenic than IDH1 wild-type genotype gliomas.",
author = "Anteneh Feyissa and Worrell, {Gregory Alan} and Tatum, {William O.} and Deependra Mahato and Benjamin Brinkmann and Steven Rosenfeld and Karim Refaey and Bechtle, {Perry S.} and Alfredo Quinones-Hinojosa",
year = "2018",
month = "3",
day = "27",
doi = "10.1212/WNL.0000000000005216",
language = "English (US)",
volume = "90",
pages = "e1119--e1125",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "13",

}

TY - JOUR

T1 - High-frequency oscillations in awake patients undergoing brain tumor-related epilepsy surgery

AU - Feyissa, Anteneh

AU - Worrell, Gregory Alan

AU - Tatum, William O.

AU - Mahato, Deependra

AU - Brinkmann, Benjamin

AU - Rosenfeld, Steven

AU - Refaey, Karim

AU - Bechtle, Perry S.

AU - Quinones-Hinojosa, Alfredo

PY - 2018/3/27

Y1 - 2018/3/27

N2 - Objective To examine the relationship between high-frequency oscillations (HFOs) and the presence of preoperative seizures, World Health Organization tumor grade, and isocitrate dehydrogenase 1 (IDH1) mutational status in gliomas. Methods We retrospectively studied intraoperative electrocorticography recorded in 16 patients with brain tumor (12 presenting with seizures) who underwent awake craniotomy and surgical resection between September 2016 and June 2017. The number and distribution of HFOs were determined and quantified visually and with an automated HFO detector. Results Five patients had low-grade (1 with grade I and 4 with grade II) and 11 had high-grade (6 with grade III and 5 with grade IV) brain tumors. An IDH1 mutation was found in 6 patients. Patients with a history of preoperative seizures were more likely to have HFOs than those without preoperative seizures (9 of 12 vs 0 of 4, p = 0.02). The rate of HFOs was higher in patients with IDH1 mutant (mean 7.2 per minute) than IDH wild-type (mean 2.3 per minute) genotype (p = 0.03). Conclusions HFOs are common in brain tumor-related epilepsy, and HFO rate may be a useful measure of epileptogenicity in gliomas. Our findings further support the notion that IDH1 mutant genotype is more epileptogenic than IDH1 wild-type genotype gliomas.

AB - Objective To examine the relationship between high-frequency oscillations (HFOs) and the presence of preoperative seizures, World Health Organization tumor grade, and isocitrate dehydrogenase 1 (IDH1) mutational status in gliomas. Methods We retrospectively studied intraoperative electrocorticography recorded in 16 patients with brain tumor (12 presenting with seizures) who underwent awake craniotomy and surgical resection between September 2016 and June 2017. The number and distribution of HFOs were determined and quantified visually and with an automated HFO detector. Results Five patients had low-grade (1 with grade I and 4 with grade II) and 11 had high-grade (6 with grade III and 5 with grade IV) brain tumors. An IDH1 mutation was found in 6 patients. Patients with a history of preoperative seizures were more likely to have HFOs than those without preoperative seizures (9 of 12 vs 0 of 4, p = 0.02). The rate of HFOs was higher in patients with IDH1 mutant (mean 7.2 per minute) than IDH wild-type (mean 2.3 per minute) genotype (p = 0.03). Conclusions HFOs are common in brain tumor-related epilepsy, and HFO rate may be a useful measure of epileptogenicity in gliomas. Our findings further support the notion that IDH1 mutant genotype is more epileptogenic than IDH1 wild-type genotype gliomas.

UR - http://www.scopus.com/inward/record.url?scp=85052548881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052548881&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000005216

DO - 10.1212/WNL.0000000000005216

M3 - Article

C2 - 29490917

AN - SCOPUS:85052548881

VL - 90

SP - e1119-e1125

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 13

ER -