High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation

Shih Sung Chuang; Chuan Lee; Rifat A. Hamoudi; Hongxiang Liu; Po Shing Lee; Hongtao Ye; Tim C. Diss; Ahmet Dogan; Peter G. Isaacson; Ming Qing Du

doi:10.1046/j.1365-2141.2003.04035.x

High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation

Shih Sung Chuang, Chuan Lee, Rifat A. Hamoudi, Hongxiang Liu, Po Shing Lee, Hongtao Ye, Tim C. Diss, Ahmet Dogan, Peter G. Isaacson, Ming Qing Du

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients. Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.

Original language	English (US)
Pages (from-to)	97-100
Number of pages	4
Journal	British Journal of Haematology
Volume	120
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2141.2003.04035.x
State	Published - 2003

Keywords

High-grade transformation
MALT lymphoma
RT-PCR
p53
t(11;18)

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2003.04035.x

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Chuang, S. S., Lee, C., Hamoudi, R. A., Liu, H., Lee, P. S., Ye, H., Diss, T. C., Dogan, A., Isaacson, P. G., & Du, M. Q. (2003). High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation. British Journal of Haematology, 120(1), 97-100. https://doi.org/10.1046/j.1365-2141.2003.04035.x

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abstract = "t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients. Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.",

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AU - Chuang, Shih Sung

AU - Lee, Chuan

AU - Hamoudi, Rifat A.

AU - Liu, Hongxiang

AU - Lee, Po Shing

AU - Ye, Hongtao

AU - Diss, Tim C.

AU - Dogan, Ahmet

AU - Isaacson, Peter G.

AU - Du, Ming Qing

PY - 2003

Y1 - 2003

N2 - t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients. Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.

AB - t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients. Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.

KW - High-grade transformation

KW - MALT lymphoma

KW - RT-PCR

KW - p53

KW - t(11;18)

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High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation

Abstract

Keywords

ASJC Scopus subject areas

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