High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation

Shih Sung Chuang, Chuan Lee, Rifat A. Hamoudi, Hongxiang Liu, Po Shing Lee, Hongtao Ye, Tim C. Diss, Ahmet Dogan, Peter G. Isaacson, Ming Qing Du

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients. Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalBritish journal of haematology
Volume120
Issue number1
DOIs
StatePublished - 2003

Keywords

  • High-grade transformation
  • MALT lymphoma
  • RT-PCR
  • p53
  • t(11;18)

ASJC Scopus subject areas

  • Hematology

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