High frequency of HLA-A*0103 allele in a Somali population

Gregory A. Poland, Youvraj Sohni, Michael Domanico, Cindy M. Kroning, Steven R. DeGoey, Mouhammed Jimale, Robert M. Jacobson, S. Breanndan Moore

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report the existence of class I HLA allele A*0103 in an ethnic group (Somali) where this allele has not been reported. This allele was discovered in a study to examine the relationship between HLA alleles and humoral antibody response to measles vaccine among recent immigrants from Somalia to Olmsted County, Minnesota. We initially used polymerase chain reaction-sequence-specific primers (PCR-SSP) to carry out HLA class I typing. Based on PCR-SSP, 55 subjects were assigned the allele HLA-A*0101. Following direct DNA sequencing of the PCR products, 37 of the 55 subjects (67.3%) that were initially assigned the A*0101 allele were found to actually be A*0103. Our data are significant because it demonstrates that many of the previously typed A*0101 individuals are actually A*0103 as the SSP or sequence-specific oligonucleotide probes method cannot distinguish between the two alleles. Lastly, this is the first identification of this allele in the homozygous state.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalHuman Immunology
Volume62
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Alleles
Population
Polymerase Chain Reaction
Somalia
Measles Vaccine
HLA-A Antigens
Oligonucleotide Probes
HLA-A*01:03 antigen
DNA Sequence Analysis
Ethnic Groups
Antibody Formation

Keywords

  • Class I
  • HLA
  • PCR-SSP

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Poland, G. A., Sohni, Y., Domanico, M., Kroning, C. M., DeGoey, S. R., Jimale, M., ... Breanndan Moore, S. (2001). High frequency of HLA-A*0103 allele in a Somali population. Human Immunology, 62(2), 197-200. https://doi.org/10.1016/S0198-8859(00)00238-X

High frequency of HLA-A*0103 allele in a Somali population. / Poland, Gregory A.; Sohni, Youvraj; Domanico, Michael; Kroning, Cindy M.; DeGoey, Steven R.; Jimale, Mouhammed; Jacobson, Robert M.; Breanndan Moore, S.

In: Human Immunology, Vol. 62, No. 2, 2001, p. 197-200.

Research output: Contribution to journalArticle

Poland, GA, Sohni, Y, Domanico, M, Kroning, CM, DeGoey, SR, Jimale, M, Jacobson, RM & Breanndan Moore, S 2001, 'High frequency of HLA-A*0103 allele in a Somali population', Human Immunology, vol. 62, no. 2, pp. 197-200. https://doi.org/10.1016/S0198-8859(00)00238-X
Poland GA, Sohni Y, Domanico M, Kroning CM, DeGoey SR, Jimale M et al. High frequency of HLA-A*0103 allele in a Somali population. Human Immunology. 2001;62(2):197-200. https://doi.org/10.1016/S0198-8859(00)00238-X
Poland, Gregory A. ; Sohni, Youvraj ; Domanico, Michael ; Kroning, Cindy M. ; DeGoey, Steven R. ; Jimale, Mouhammed ; Jacobson, Robert M. ; Breanndan Moore, S. / High frequency of HLA-A*0103 allele in a Somali population. In: Human Immunology. 2001 ; Vol. 62, No. 2. pp. 197-200.
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