High expression of SNIP1 correlates with poor prognosis in Non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro

Hyo Sung Jeon, Yi Young Choi, Junya Fukuoka, Makiko Fujii, Lyudmila A. Lyakh, Sang Hyun Song, William D. Travis, Jae Yong Park, Jin Jen

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The Rb tumor suppressor gene performs a critical role in controlling cell proliferation and tumorigenesis; it recruits HDAC1 protein into the E2F complexes to repress transcription. In this study, we demonstrate that SNIP1, RB and HDAC1 were significantly expressed in same lung cancer tissues in a tissue microarray (TMA) containing 300 non-small cell lung cancers (NSCLC). High expression level of SNIP1 in tumor patients was significantly correlated with poor prognosis in NSCLC (log-rank P for OS. = 0.01, log-rank P for DFS. = 0.001). Functionally, SNIP1 competes with HDAC1 for binding to RB and reduces HDAC activity in vitro. Knockdown of SNIP1 reduced colony formation ability of lung cancer cells. These findings may indicate the involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalLung Cancer
Volume82
Issue number1
DOIs
StatePublished - Oct 1 2013

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Keywords

  • HDAC1
  • Lung cancer
  • Prognosis
  • RB
  • SNIP1

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Jeon, H. S., Choi, Y. Y., Fukuoka, J., Fujii, M., Lyakh, L. A., Song, S. H., Travis, W. D., Park, J. Y., & Jen, J. (2013). High expression of SNIP1 correlates with poor prognosis in Non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro. Lung Cancer, 82(1), 24-30. https://doi.org/10.1016/j.lungcan.2013.07.015