@article{5e3a2c24bba747f981299d6b06714478,
title = "High expression of SNIP1 correlates with poor prognosis in Non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro",
abstract = "The Rb tumor suppressor gene performs a critical role in controlling cell proliferation and tumorigenesis; it recruits HDAC1 protein into the E2F complexes to repress transcription. In this study, we demonstrate that SNIP1, RB and HDAC1 were significantly expressed in same lung cancer tissues in a tissue microarray (TMA) containing 300 non-small cell lung cancers (NSCLC). High expression level of SNIP1 in tumor patients was significantly correlated with poor prognosis in NSCLC (log-rank P for OS. = 0.01, log-rank P for DFS. = 0.001). Functionally, SNIP1 competes with HDAC1 for binding to RB and reduces HDAC activity in vitro. Knockdown of SNIP1 reduced colony formation ability of lung cancer cells. These findings may indicate the involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction.",
keywords = "HDAC1, Lung cancer, Prognosis, RB, SNIP1",
author = "Jeon, {Hyo Sung} and Choi, {Yi Young} and Junya Fukuoka and Makiko Fujii and Lyakh, {Lyudmila A.} and Song, {Sang Hyun} and Travis, {William D.} and Park, {Jae Yong} and Jin Jen",
note = "Funding Information: This study included patients ( = 83) with pathological stages I, II, or IIIA (micro-invasive N2) NSCLC who underwent curative surgical resection at the Kyungpook National University Hospital (Daegu, Korea) between January 2001 and December 2008. All the patients included in this study were ethnic Koreans. Patients who underwent chemotherapy or radiotherapy prior to surgery were excluded to avoid the effects on DNA. All the tissues were obtained at the time of surgery and then rapidly frozen in liquid nitrogen and stored at −80 °C until the relevant bioassays were conducted. This study was provided by the National Biobank of Korea – Kyungpook National University Hospital (KNUH), which is supported by the Ministry of Health, Welfare and Family Affairs. All materials derived from the National Biobank of Korea – KNUH were obtained under institutional review board (IRB)-approved protocols (Approval No., KNUHBIO_10-1016). n Funding Information: This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology ( NRF2010-0004700 ). ",
year = "2013",
month = oct,
doi = "10.1016/j.lungcan.2013.07.015",
language = "English (US)",
volume = "82",
pages = "24--30",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "1",
}