High density scalp EEG in frontal lobe epilepsy

Anteneh Feyissa, Jeffrey W. Britton, Jamie Van Gompel, Terrance L. Lagerlund, Elson So, Lily Wong-Kisiel, Gregory D Cascino, Benjamin H. Brinkman, Cindy L. Nelson, Robert Watson, Gregory Alan Worrell

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose Localization of seizures in frontal lobe epilepsy using the 10–20 system scalp EEG is often challenging because neocortical seizure can spread rapidly, significant muscle artifact, and the suboptimal spatial resolution for seizure generators involving mesial frontal lobe cortex. Our aim in this study was to determine the value of visual interpretation of 76 channel high density EEG (hdEEG) monitoring (10-10 system) in patients with suspected frontal lobe epilepsy, and to evaluate concordance with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional EEG, and intracranial EEG (iEEG). Methods We performed a retrospective cohort study of 14 consecutive patients who underwent hdEEG monitoring for suspected frontal lobe seizures. The gold standard for localization was considered to be iEEG. Concordance of hdEEG findings with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional 10–20 EEG, and iEEG as well as correlation of hdEEG localization with surgical outcome were examined. Results hdEEG localization was concordant with iEEG in 12/14 and was superior to conventional EEG 3/14 (p < 0.01) and SISCOM 3/12 (p < 0.01). hdEEG correctly lateralized seizure onset in 14/14 cases, compared to 9/14 (p = 0.04) cases with conventional EEG. Seven patients underwent surgical resection, of whom five were seizure free. Conclusions hdEEG monitoring should be considered in patients with suspected frontal epilepsy requiring localization of epileptogenic brain. hdEEG may assist in developing a hypothesis for iEEG monitoring and could potentially augment EEG source localization.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalEpilepsy Research
Volume129
DOIs
StatePublished - Jan 1 2017

Keywords

  • Drug resistant epilepsy
  • Epilepsy surgery
  • Frontal lobe epilepsy
  • High density EEG
  • Midline and parasagittal
  • SISCOM
  • Source localization

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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