Hidden 19S IgM rheumatoid factor in adults with juvenile rheumatoid arthritis onset

J. C. Speiser; T. L. Moore; T. D. Weiss; A. R. Baldassare; S. C. Ross; T. G. Osborn; R. W. Dorner; J. Zuckner

doi:10.1136/ard.44.5.294

Hidden 19S IgM rheumatoid factor in adults with juvenile rheumatoid arthritis onset

J. C. Speiser, T. L. Moore, T. D. Weiss, A. R. Baldassare, S. C. Ross, T. G. Osborn, R. W. Dorner, J. Zuckner

Rheumatology

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8 Scopus citations

Abstract

Forty-eight adult patients with juvenile rheumatoid arthritis (RA) (onset before age 16 years) were evaluated at the age of 17 years or more for the presence of hidden 19S IgM rheumatoid factors (RF), i.e., 19S IgM RF that can be detected by the complement-dependent haemolytic assay in the IgM-containing fraction after separation of the serum by acid gel filtration. The average age of the patients was 25.3 years. The mean duration of disease was 16.5 years. Thirty-two of 48 patients (67%) showed the presence of hidden 19S IgM RF in their serum. Disease activity correlated with hidden RF titres in 62% (55/88) of the evaluations. The results indicate that patients with seronegative JRA onseet continue to have significant titres of hidden 19S IgM RF in their sera into early adulthood.

Original language	English (US)
Pages (from-to)	294-298
Number of pages	5
Journal	Annals of the rheumatic diseases
Volume	44
Issue number	5
DOIs	https://doi.org/10.1136/ard.44.5.294
State	Published - 1985

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
General Biochemistry, Genetics and Molecular Biology

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title = "Hidden 19S IgM rheumatoid factor in adults with juvenile rheumatoid arthritis onset",

abstract = "Forty-eight adult patients with juvenile rheumatoid arthritis (RA) (onset before age 16 years) were evaluated at the age of 17 years or more for the presence of hidden 19S IgM rheumatoid factors (RF), i.e., 19S IgM RF that can be detected by the complement-dependent haemolytic assay in the IgM-containing fraction after separation of the serum by acid gel filtration. The average age of the patients was 25.3 years. The mean duration of disease was 16.5 years. Thirty-two of 48 patients (67%) showed the presence of hidden 19S IgM RF in their serum. Disease activity correlated with hidden RF titres in 62% (55/88) of the evaluations. The results indicate that patients with seronegative JRA onseet continue to have significant titres of hidden 19S IgM RF in their sera into early adulthood.",

author = "Speiser, {J. C.} and Moore, {T. L.} and Weiss, {T. D.} and Baldassare, {A. R.} and Ross, {S. C.} and Osborn, {T. G.} and Dorner, {R. W.} and J. Zuckner",

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T1 - Hidden 19S IgM rheumatoid factor in adults with juvenile rheumatoid arthritis onset

AU - Speiser, J. C.

AU - Moore, T. L.

AU - Weiss, T. D.

AU - Baldassare, A. R.

AU - Ross, S. C.

AU - Osborn, T. G.

AU - Dorner, R. W.

AU - Zuckner, J.

PY - 1985

Y1 - 1985

N2 - Forty-eight adult patients with juvenile rheumatoid arthritis (RA) (onset before age 16 years) were evaluated at the age of 17 years or more for the presence of hidden 19S IgM rheumatoid factors (RF), i.e., 19S IgM RF that can be detected by the complement-dependent haemolytic assay in the IgM-containing fraction after separation of the serum by acid gel filtration. The average age of the patients was 25.3 years. The mean duration of disease was 16.5 years. Thirty-two of 48 patients (67%) showed the presence of hidden 19S IgM RF in their serum. Disease activity correlated with hidden RF titres in 62% (55/88) of the evaluations. The results indicate that patients with seronegative JRA onseet continue to have significant titres of hidden 19S IgM RF in their sera into early adulthood.

AB - Forty-eight adult patients with juvenile rheumatoid arthritis (RA) (onset before age 16 years) were evaluated at the age of 17 years or more for the presence of hidden 19S IgM rheumatoid factors (RF), i.e., 19S IgM RF that can be detected by the complement-dependent haemolytic assay in the IgM-containing fraction after separation of the serum by acid gel filtration. The average age of the patients was 25.3 years. The mean duration of disease was 16.5 years. Thirty-two of 48 patients (67%) showed the presence of hidden 19S IgM RF in their serum. Disease activity correlated with hidden RF titres in 62% (55/88) of the evaluations. The results indicate that patients with seronegative JRA onseet continue to have significant titres of hidden 19S IgM RF in their sera into early adulthood.

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Hidden 19S IgM rheumatoid factor in adults with juvenile rheumatoid arthritis onset

Abstract

ASJC Scopus subject areas

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