Heteroconjugate antibodies enhance cell-mediated anti-herpes simplex virus immunity in vivo

Lesley M. Voss; Chella S. David; Stephen D. Showalter; Carlos V. Paya; Paul J. Leibson

doi:10.1093/intimm/4.3.417

Heteroconjugate antibodies enhance cell-mediated anti-herpes simplex virus immunity in vivo

Lesley M. Voss, Chella S. David, Stephen D. Showalter, Carlos V. Paya, Paul J. Leibson

Immunology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Heteroconjugate antibodies are generated by covalently linking two mAbs with different specificities. When antl-CD3 mAb, capable of activating effector T cells, is coupled to anti-herpes simplex virus (HSV) mAb, which binds HSV antigens on virally-lnfected target cells, the resulting heteroconjugate antibody can be used In vitro to enhance anti-HSV immunity. Specifically, these heteroconjugate antibodies can augment antl-HSV immunity among lymphocytes previously lacking cytotoxicity against HSV-infected target cells. However, the efficacy of these specialized reagents in enhancing anti-HSV Immunity in vivo has not been determined. We report here that anti-HSV heteroconjugates used In an adoptive transfer murine model of HSV-1 infection inhibited HSV replication in vivo and Improved long-term survival. These results demonstrate that heteroconjugate antibodies have a potential therapeutic role in enhancement of anti-HSV immunity.

Original language	English (US)
Pages (from-to)	417-420
Number of pages	4
Journal	International Immunology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1093/intimm/4.3.417
State	Published - Mar 1992

Keywords

Adoptive transfer
Anti-CD3 mAb
Immunotherapy
Viral antigens

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1093/intimm/4.3.417

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title = "Heteroconjugate antibodies enhance cell-mediated anti-herpes simplex virus immunity in vivo",

abstract = "Heteroconjugate antibodies are generated by covalently linking two mAbs with different specificities. When antl-CD3 mAb, capable of activating effector T cells, is coupled to anti-herpes simplex virus (HSV) mAb, which binds HSV antigens on virally-lnfected target cells, the resulting heteroconjugate antibody can be used In vitro to enhance anti-HSV immunity. Specifically, these heteroconjugate antibodies can augment antl-HSV immunity among lymphocytes previously lacking cytotoxicity against HSV-infected target cells. However, the efficacy of these specialized reagents in enhancing anti-HSV Immunity in vivo has not been determined. We report here that anti-HSV heteroconjugates used In an adoptive transfer murine model of HSV-1 infection inhibited HSV replication in vivo and Improved long-term survival. These results demonstrate that heteroconjugate antibodies have a potential therapeutic role in enhancement of anti-HSV immunity.",

keywords = "Adoptive transfer, Anti-CD3 mAb, Immunotherapy, Viral antigens",

author = "Voss, {Lesley M.} and David, {Chella S.} and Showalter, {Stephen D.} and Paya, {Carlos V.} and Leibson, {Paul J.}",

year = "1992",

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doi = "10.1093/intimm/4.3.417",

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AU - Voss, Lesley M.

AU - David, Chella S.

AU - Showalter, Stephen D.

AU - Paya, Carlos V.

AU - Leibson, Paul J.

PY - 1992/3

Y1 - 1992/3

N2 - Heteroconjugate antibodies are generated by covalently linking two mAbs with different specificities. When antl-CD3 mAb, capable of activating effector T cells, is coupled to anti-herpes simplex virus (HSV) mAb, which binds HSV antigens on virally-lnfected target cells, the resulting heteroconjugate antibody can be used In vitro to enhance anti-HSV immunity. Specifically, these heteroconjugate antibodies can augment antl-HSV immunity among lymphocytes previously lacking cytotoxicity against HSV-infected target cells. However, the efficacy of these specialized reagents in enhancing anti-HSV Immunity in vivo has not been determined. We report here that anti-HSV heteroconjugates used In an adoptive transfer murine model of HSV-1 infection inhibited HSV replication in vivo and Improved long-term survival. These results demonstrate that heteroconjugate antibodies have a potential therapeutic role in enhancement of anti-HSV immunity.

AB - Heteroconjugate antibodies are generated by covalently linking two mAbs with different specificities. When antl-CD3 mAb, capable of activating effector T cells, is coupled to anti-herpes simplex virus (HSV) mAb, which binds HSV antigens on virally-lnfected target cells, the resulting heteroconjugate antibody can be used In vitro to enhance anti-HSV immunity. Specifically, these heteroconjugate antibodies can augment antl-HSV immunity among lymphocytes previously lacking cytotoxicity against HSV-infected target cells. However, the efficacy of these specialized reagents in enhancing anti-HSV Immunity in vivo has not been determined. We report here that anti-HSV heteroconjugates used In an adoptive transfer murine model of HSV-1 infection inhibited HSV replication in vivo and Improved long-term survival. These results demonstrate that heteroconjugate antibodies have a potential therapeutic role in enhancement of anti-HSV immunity.

KW - Adoptive transfer

KW - Anti-CD3 mAb

KW - Immunotherapy

KW - Viral antigens

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Heteroconjugate antibodies enhance cell-mediated anti-herpes simplex virus immunity in vivo

Abstract

Keywords

ASJC Scopus subject areas

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